Description

(Preservative-Free Sterile Solution for Anti-Inflammatory, Analgesic, and Transdermal Support)

Pharmaceutical-Grade DMSO Injectable – Preservative-Free Formulation for Advanced Clinical Use

Dimethyl Sulfoxide (DMSO) 50 mg/mL – 30 mL is a preservative-free, sterile compounded solution intended for topical, intravesical, or parenteral administration under medical supervision. Known for its potent anti-inflammatory, analgesic, and transdermal transport properties, DMSO remains a unique and highly versatile agent in functional, integrative, and regenerative medicine.

Each milliliter of this solution contains 50 mg of high-purity DMSO, compounded in a USP <797>-compliant sterile facility, free from preservatives, parabens, or chemical stabilizers. This formulation is suitable for clinicians seeking targeted anti-inflammatory support, drug delivery facilitation, and off-label adjunctive therapy in chronic or complex conditions.

Product Details

• Active Ingredient: Dimethyl Sulfoxide (DMSO)

• Concentration: 50 mg/mL

• Volume: 30 mL sterile multi-dose vial

• Formulation: Preservative-free, non-pyrogenic injectable solution

• **Compounded in a sterile facility compliant with USP <797>

• Routes of Use: Topical, intravesical, or IV use (off-label, provider discretion)

Mechanism of Action

DMSO is a highly polar, organic solvent with unique biochemical and therapeutic properties, including:

• Free radical scavenging

• Membrane penetration and drug transport enhancement

• Cytoprotective and anti-inflammatory modulation

• Analgesic effects via peripheral and central pathways

• Reduction of edema and ischemia-induced cellular damage

Its lipid and water solubility enables deep tissue penetration, facilitating both local and systemic effects.

Key Clinical Applications

⚠️ All routes of administration should be performed only under licensed medical supervision. DMSO is not FDA-approved for all off-label uses described.

1. Anti-Inflammatory Support

DMSO has been studied in a variety of inflammatory conditions including:

• Interstitial cystitis (FDA-approved intravesical use)

• Rheumatoid and osteoarthritis

• Scleroderma and other fibrotic conditions

• Soft tissue injuries and sports medicine applications

It reduces cytokine expression (e.g., IL-6, TNF-α) and oxidative stress markers, supporting long-term inflammation management.

2. Pain Relief

Topically or parenterally applied DMSO demonstrates analgesic effects, often used in:

• Neuralgia and peripheral nerve injury

• Post-herpetic pain

• Muscle or joint pain, especially in athletes

• Chronic pain syndromes such as CRPS (Complex Regional Pain Syndrome)

3. Drug Delivery Enhancer

Due to its powerful ability to penetrate biological membranes, DMSO is used experimentally as a vehicle for other medications, enabling:

• Improved transdermal delivery

• Enhanced uptake in targeted injections

• Combination therapies in regenerative protocols

4. Adjunctive Regenerative Medicine Use

In some clinical protocols, DMSO is used as a cryoprotectant or as part of IV nutrient or stem cell delivery regimens, though such uses are off-label and investigational.

Dosing & Administration

• Topical Use: Apply with sterile technique to clean skin; 50–70% topical DMSO concentrations are typical

• Intravesical Use: For interstitial cystitis, instill under urologist supervision

• IV/IM Use: Off-label; always use with cardiac and renal monitoring

• Dose range varies by use case; provider should assess based on route, body weight, and indication

• Use only in sterile, medical environments with proper safety protocols

Storage & Stability

• Store at 20–25°C (68–77°F)

• Do not refrigerate or freeze (DMSO may crystallize)

• Protect from light and moisture

• Use sterile techniques; discard vial within 28 days after first use or per facility policy

Precautions & Safety

While generally well tolerated in controlled settings, DMSO requires specific clinical oversight:

• May produce garlic-like odor on breath or skin after administration

• Avoid in pregnancy and lactation unless physician-approved

• Use with caution in patients with liver or kidney impairment

• Monitor for local irritation, allergic reaction, or off-target drug potentiation

• Do not mix with incompatible drugs without compatibility testing

Who Should Use DMSO 50 mg/mL?

This formulation is ideal for:

• Pain and inflammation clinics

• Integrative and functional medicine practices

• Sports medicine and physical rehab providers

• Practices specializing in fibrotic or autoimmune disorders

• Urology centers treating interstitial cystitis

• Regenerative and IV therapy clinics (under proper guidance)

DMSO (PF) 50 mg/mL – 30 mL Injectable is a versatile and clinically valuable compound offering broad-spectrum biochemical activity. Its unique pharmacologic profile provides powerful anti-inflammatory and analgesic properties, while also functioning as a penetration enhancer in advanced therapy programs. When used responsibly under medical supervision, DMSO can be a key component of targeted interventions across multiple disciplines.