Description

(Long-Acting Corticosteroid Suspension for Intramuscular or Intra-Articular Use)

Potent Anti-Inflammatory Steroid for Musculoskeletal, Dermatologic, and Systemic Conditions

Triamcinolone Acetonide 40 mg/mL (Kenalog equivalent) is a high-potency, long-acting synthetic corticosteroid formulated as a sterile aqueous suspension. This 10 mL multidose vial delivers consistent, localized or systemic relief for a broad range of inflammatory and immunologic conditions, especially when oral steroid therapy is impractical or undesirable.

Designed for intramuscular (IM) or intra-articular (IA) administration, this injectable formulation is widely used by rheumatologists, orthopedists, dermatologists, pain specialists, and primary care providers to manage arthritis, joint inflammation, keloids, allergic disorders, and various chronic inflammatory syndromes.

Product Specifications

• Active Ingredient: Triamcinolone acetonide

• Concentration: 40 mg/mL

• Total Volume: 10 mL multidose vial (total 400 mg)

• Formulation: Sterile aqueous suspension (not suitable for IV use)

• Administration Routes: IM (deep muscle), intra-articular, intralesional

• Preservative: Benzyl alcohol

• Storage: 20–25°C (68–77°F); avoid freezing; shake well before use

• Equivalent Brand: Kenalog®-40

Mechanism of Action

Triamcinolone is a potent glucocorticoid that acts by:

• Suppressing the migration of polymorphonuclear leukocytes

• Reducing capillary permeability

• Inhibiting inflammatory cytokine release

• Suppressing immune response pathways

Its acetonide form offers extended duration of action due to low solubility and sustained tissue presence at the injection site, making it ideal for chronic or localized inflammation.

Clinical Indications

Triamcinolone 40 mg/mL is indicated for:

Systemic Use (IM):

• Allergic disorders (asthma, rhinitis, atopic dermatitis)

• Dermatologic conditions (psoriasis, eczema)

• Endocrine disorders (adrenal insufficiency)

• Collagen diseases (lupus, polymyositis)

• Rheumatic disorders (RA, ankylosing spondylitis)

Intra-Articular Use:

• Osteoarthritis

• Rheumatoid arthritis

• Synovitis

• Bursitis

• Tenosynovitis

Intralesional Use:

• Keloids and hypertrophic scars

• Alopecia areata

• Lichen planus

• Psoriatic plaques

• Cystic acne

Dosage and Administration

General Guidelines:

• Shake well before use to ensure uniform suspension

• Do not administer intravenously

• Use aseptic technique and proper anatomical landmarking for IA or IM injections

• Adjust dose and frequency based on condition severity and site of injection

Typical Dosing:

• IM (systemic): 40–80 mg as a single dose, repeated at 4-week intervals as needed

• Intra-articular: 10–40 mg per large joint (e.g., knee); 5–10 mg for smaller joints

• Intralesional: 1–2 mg per site (do not exceed 30 mg per session)

Frequency:

• Intra-articular or intralesional injections are usually repeated no more than every 3–4 weeks per site to minimize local tissue effects

Safety and Tolerability

Triamcinolone is generally well tolerated when used appropriately, though it carries risks typical of corticosteroids, especially with repeated or high-dose use.

Local side effects:

• Subcutaneous fat atrophy

• Skin hypopigmentation at injection site

• Tendon rupture (rare with IA use)

• Post-injection flare (mild transient pain)

Systemic effects (with repeated IM use):

• Adrenal suppression

• Hyperglycemia

• Cushingoid features

• Osteoporosis

• Immunosuppression

Minimize systemic exposure by limiting frequency and rotating injection sites.

Contraindications and Precautions

Contraindications:

• Systemic fungal infections

• Known hypersensitivity to triamcinolone or excipients

• Intramuscular administration in idiopathic thrombocytopenic purpura

Cautions:

• Avoid injecting into unstable joints

• Do not inject into infected or inflamed tissue

• Use caution in patients with diabetes, hypertension, or active infections

Monitoring:

• Blood glucose in diabetic patients

• Joint stability and cartilage integrity with repeat IA injections

• Signs of local skin thinning or discoloration with intralesional therapy

Storage and Handling

• Store at 20–25°C (68–77°F)

• Do not freeze

• Shake vigorously before use

• Use only sterile technique

• Multi-dose vial; discard if contaminated or expired

Ideal For Use In:

• Rheumatology and orthopedic clinics

• Dermatology and aesthetic practices

• Primary care and sports medicine

• Allergy and immunology centers

• Pain management and rehabilitation units

Triamcinolone Acetonide 40 mg/mL Injection (Kenalog Equivalent) – 10 mL provides long-lasting anti-inflammatory and immunosuppressive effects for a wide variety of clinical conditions. Whether managing arthritic joints, dermal lesions, or systemic allergic responses, this versatile corticosteroid formulation delivers reliable outcomes with durable relief. Its injectable suspension format makes it a mainstay in both acute care and chronic disease management protocols.