Description

(Central Appetite Suppressant and Cognitive Enhancer for Advanced Weight Management and Neuroperformance)

Dual-Action Weight Loss and Cognitive Support Through Neurotransmitter Modulation

Tesofensine is a centrally acting, research-based compound originally investigated for neurodegenerative disorders such as Alzheimer’s and Parkinson’s. However, clinical trials revealed a potent appetite-suppressing and fat-loss effect, leading to its repurposing as a promising agent in medical weight loss and metabolic therapy. This oral formulation—500 mcg per capsule, 30-count supply—delivers a precise, clinician-calibrated dose for daily use in comprehensive weight management and lifestyle optimization protocols.

Though sometimes confused with Ibutamoren (MK-677) due to their mutual role in body composition and performance enhancement, Tesofensine and Ibutamoren are pharmacologically distinct. This compounded product is Tesofensine only, not MK-677. It exerts its effects through central nervous system neurotransmitter reuptake inhibition, affecting dopamine, norepinephrine, and serotonin, resulting in enhanced satiety, energy, motivation, and mood stability.

Product Overview

• Active Ingredient: Tesofensine 
• Dose: 500 mcg (0.5 mg) per capsule 
• Capsule Count: 30 capsules per bottle (30-day supply) 
• Administration Route: Oral 
• Suggested Use: 1 capsule daily or as directed by a healthcare provider 
• Storage: Store in a cool, dry place at room temperature; avoid excessive heat or moisture 
• Use: Physician-supervised weight loss or performance-enhancement programs 

What Is Tesofensine?

Tesofensine is a monoamine reuptake inhibitor originally developed as a treatment for Parkinson’s disease and Alzheimer’s disease. During early-stage trials, it demonstrated a significant reduction in appetite and body weight, without muscle loss or stimulant crash—making it an attractive compound for targeted weight loss and metabolic optimization.

Its key mechanism is triple monoamine reuptake inhibition (TRI)—blocking the reuptake of:

• Dopamine – Enhancing motivation and reward sensitivity 
• Norepinephrine – Boosting alertness and metabolic drive 
• Serotonin – Supporting satiety and mood balance 

Mechanism of Action

Tesofensine works primarily in the hypothalamus, a key brain region that controls hunger and energy balance. Its effects include:

• Reduced appetite and food cravings 
• Increased resting metabolic rate 
• Decreased caloric intake without loss of muscle mass 
• Elevated mood and motivation for physical activity 
• Enhanced neurotransmitter tone for stable focus and energy 

The result is a multi-dimensional impact on fat loss, energy, and cognitive performance—without the cardiovascular overstimulation associated with traditional stimulants.

Clinical and Functional Applications

1. Medical Weight Loss

• Reduces hunger and emotional eating 
• Supports calorie control during dietary regimens 
• Helps sustain weight loss in patients resistant to traditional methods 

2. Metabolic Optimization

• Increases basal metabolic rate (BMR) 
• Enhances lipolysis and fat oxidation 
• Preserves lean muscle during caloric restriction 

3. Cognitive Enhancement

• Improves alertness, mood, and executive function 
• Used off-label in performance and nootropic programs 

4. Post-Obesity Weight Maintenance

• Useful for maintaining long-term results after significant weight loss 
• Aids in neurochemical rebalancing post-diet adaptation 

Dosing and Administration

• Typical dose: 500 mcg orally once daily, preferably in the morning 
• May be increased to 1 mg/day depending on provider recommendation and tolerance 
• Best taken on an empty stomach to maximize bioavailability 
• Not recommended to take late in the day to avoid sleep disruption 

Cycle duration is typically 6–12 weeks, followed by evaluation and possible repeat course.

Safety and Tolerability

Tesofensine is generally well tolerated, with a favorable safety profile in multiple clinical trials. It does not act as a direct stimulant, and has minimal abuse potential.

Mild, transient side effects may include:

• Dry mouth 
• Mild headache 
• Sleep disturbance (if taken late in the day) 
• Slight increase in heart rate or blood pressure (monitor if sensitive) 

These are typically dose-dependent and diminish over time.

Contraindications

Tesofensine is not recommended for individuals who:

• Are pregnant or breastfeeding 
• Have uncontrolled hypertension or cardiovascular disease 
• Are currently using other monoamine reuptake inhibitors (e.g., certain antidepressants) 
• Have a history of severe psychiatric illness (unless under active management) 

All use should be supervised by a licensed healthcare provider with appropriate monitoring.

Storage Instructions

• Store at room temperature in a dry, cool location 
• Keep container tightly closed and away from children 
• Do not use past expiration date 

Why Choose Tesofensine 500 mcg?

• Clinically researched for safe, sustainable weight loss 
• Powerful appetite suppression without stimulant effects 
• Supports mood, motivation, and metabolic clarity 
• Ideal for integrative weight loss programs, especially in resistant or rebound-prone patients 
• Can be paired with peptides, NAD+, or GLP-1 therapies for compounded results 

Summary

Tesofensine 500 mcg Capsules (30 Count) represent a sophisticated, neurochemically targeted solution for individuals seeking to overcome plateaus in weight loss, appetite control, and mental clarity. With its dual action on metabolism and brain function, Tesofensine offers a modern, science-backed option for providers looking to deliver safe and lasting outcomes in weight management and cognitive wellness.