Description

(Targeted Multi-Agent Therapy for Anal Itching, Inflammation, and Irritation Relief)

Comprehensive Topical Relief for Anal Itching and Inflammatory Skin Conditions

This Pruritus Ani Preparation combines four therapeutic agents—Hydrocortisone 2%, Iodoquinol 1%, Metronidazole 10%, and Zinc Oxide 2%—to provide targeted relief from chronic anal itching (pruritus ani) and associated symptoms such as irritation, burning, and skin inflammation. Dispensed in a 30-gram topical ointment, this compounded formulation is designed for short- to mid-term use under medical supervision, offering a multifactorial approach to managing one of the most persistent and frustrating anorectal conditions.

Whether caused by moisture imbalance, contact dermatitis, infection, or inflammatory skin disorders, this preparation addresses both symptoms and underlying causes.

Product Overview

• Active Ingredients:
  • Hydrocortisone 2% – Corticosteroid for anti-inflammatory and anti-itch effect

  • Iodoquinol 1% – Antifungal and antibacterial agent

  • Metronidazole 10% – Antimicrobial and anti-inflammatory

  • Zinc Oxide 2% – Barrier protectant and skin soother

• Formulation: Ointment base, optimized for perianal and mucosal skin use

• Volume: 30 grams per tube/jar

• Route: External topical use only

• Storage: Store at room temperature (20–25°C); keep sealed and clean

• Prescription-only: Compounded by pharmacy for individualized patient care

How It Works

This formulation uses a multimodal approach to address the key pathophysiological factors in pruritus ani, including inflammation, microbial overgrowth, skin barrier dysfunction, and moisture-related irritation.

1. Hydrocortisone 2% – Inflammation and Itch Suppression

Hydrocortisone is a mid-strength corticosteroid that helps calm local immune responses in irritated or overactive skin. It is effective in reducing:

• Persistent itch

• Swelling and redness

• Localized discomfort after wiping or bowel movements

2. Iodoquinol 1% – Antifungal and Antibacterial Protection

Iodoquinol is an antimicrobial with activity against both fungi and certain bacteria, including those commonly present on the perianal skin. It helps:

• Prevent secondary infection

• Reduce microbe-related inflammation and irritation

• Support skin recovery in moist, occluded areas

3. Metronidazole 10% – Anti-inflammatory and Anaerobic Antimicrobial

Metronidazole, when applied topically, is used off-label for its ability to reduce oxidative stress, suppress inflammation, and combat anaerobic bacteria—particularly useful in patients with suspected bacterial overgrowth or perianal dermatitis.

4. Zinc Oxide 2% – Skin Barrier and Soothing Agent

Zinc oxide is a time-tested protectant that forms a barrier film on the skin, shielding irritated tissue from moisture, stool, or clothing friction. It also:

• Reduces chafing and maceration

• Supports skin healing and dryness control

• Offers a mild astringent and anti-inflammatory effect

Indications

This preparation is ideal for the treatment of:

• Chronic pruritus ani (idiopathic or secondary)

• Inflammatory skin conditions of the perianal area

• Moisture-associated dermatitis

• Mild-to-moderate perianal infections or colonization

• Post-treatment support in yeast-related or bacterial skin irritation

It is often prescribed when standard over-the-counter barrier creams and hydrocortisone formulations have failed to provide sufficient relief.

Dosing and Administration

• Recommended use: Apply a thin layer to the affected area 1–3 times daily, typically after bowel movements and before bedtime

• Method: Use a clean fingertip or applicator; avoid excessive rubbing

• Duration: Typically used for 7 to 14 days, depending on symptom response

• Precaution: Do not occlude the area unless specifically directed by your provider

Use only externally and as prescribed. Wash hands thoroughly after application.

Safety and Tolerability

This ointment is well tolerated when used appropriately for short treatment durations.

Possible mild side effects include:

• Temporary tingling or burning

• Dryness or scaling with prolonged use

• Rare allergic or hypersensitivity reactions

Avoid long-term use of topical steroids in the same area to reduce the risk of skin thinning (atrophy).

Contraindications

Do not use if:

• You are allergic to hydrocortisone, metronidazole, iodoquinol, or zinc oxide

• You have viral, fungal, or bacterial infections of the area without medical approval

• You are using other perianal steroid treatments concurrently unless approved

• You are pregnant or breastfeeding, unless directed by a healthcare provider

Storage & Handling

• Store at room temperature (20–25°C / 68–77°F)

• Keep tightly sealed

• Avoid contamination—do not dip fingers directly into the jar if present

• Use within the pharmacy-assigned beyond-use date (BUD)

Why Choose This Compounded Pruritus Ani Formula?

• Combines four active agents for inflammation, infection control, itch relief, and skin barrier protection

• Targets both symptoms and common root causes of pruritus ani

• Custom-compounded for clinical strength and patient-specific needs

• Superior to single-agent OTC products in managing persistent, recurrent irritation

• Trusted by dermatologists, gastroenterologists, and colorectal specialists

Summary

Pruritus Ani Preparation – Hydrocortisone 2% / Iodoquinol 1% / Metronidazole 10% / Zinc Oxide 2% Ointment (30g) offers a powerful, well-balanced solution for patients suffering from anal itching, inflammation, and skin sensitivity. With its anti-inflammatory, antimicrobial, and protective components, this preparation supports symptom resolution and skin healing, while addressing potential underlying microbial contributors to persistent pruritus ani.