Description

(Advanced Nootropic and Neuroprotective Peptide for Cognitive Enhancement and Mood Regulation)

Cutting-Edge Peptide-Based Support for Brain Health, Mental Clarity, and Stress Resilience

PE 22-28, a synthetic peptide fragment derived from the parent compound SEMAX, represents the next generation of neuroprotective and cognitive-enhancing therapies. Delivered via nasal spray, this formulation offers a non-invasive, fast-acting method to deliver neuroactive peptides directly to the central nervous system, bypassing first-pass metabolism and maximizing bioavailability.

This 20 mg nasal spray format is intended for use under medical supervision as part of protocols targeting brain performance, stress resilience, neurological recovery, and inflammatory modulation—areas where conventional pharmacology often falls short. PE 22-28 is gaining recognition as a key therapeutic in longevity medicine, executive performance, and post-illness cognitive recovery.

Product Summary

• Active Ingredient: PE 22-28 (synthetic heptapeptide derived from ACTH4–10 fragment)
• Strength: 20 mg per bottle
• Delivery: Metered intranasal spray
• Route: Intranasal administration only
• Storage: Refrigerate at 2–8°C; protect from light
• Indication: For professional use only under supervision in cognitive, neurological, or neuroimmune support protocols

What Is PE 22-28?

PE 22-28 is a short neuropeptide, specifically a heptapeptide fragment of the larger ACTH(4-10) analog, SEMAX. This compound retains SEMAX’s nootropic, neurotrophic, and anti-inflammatory properties, while offering a more targeted and potent effect on the central nervous system (CNS).

It is classified as a synthetic melanocortin analog, meaning it binds and modulates melanocortin receptors (primarily MC4R and MC5R) in the brain—receptors involved in mood regulation, neuroplasticity, and immune response. Because of its small size and structure, PE 22-28 crosses the blood-brain barrier efficiently and begins acting within minutes of administration.

Mechanism of Action

PE 22-28 exerts its effects through:

• Modulation of neurotrophic factors like brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)
• Reduction of neuroinflammatory cytokines such as IL-1β and TNF-α
• Support of synaptic plasticity and memory encoding
• Antioxidant and anti-apoptotic activity in CNS tissue
• Mild dopaminergic and serotonergic regulation, contributing to mood stabilization and focus
• Activation of melanocortin receptors, which help modulate immune, endocrine, and neural signaling

This peptide works on both the neurological and immune systems, making it ideal for treating cognitive fog, low mood, neurological inflammation, and cognitive decline due to aging or illness.

Functional & Clinical Applications

1. Cognitive Enhancement

• Improves working memory and processing speed
• Enhances executive function and decision-making
• Commonly used in high-performance and academic settings

2. Mood Regulation

• Mild anxiolytic and antidepressant effects (non-sedating)
• Can support patients with depression, burnout, or emotional fatigue

3. Post-Illness Recovery (e.g., Long COVID)

• Reduces neuroinflammation
• Supports recovery from viral brain fog, fatigue, and mental dullness

4. Neuroprotection

• Promotes resilience in traumatic brain injury (TBI) and stroke recovery
• Offers cellular protection against oxidative stress and excitotoxicity

5. Longevity and Preventive Medicine

• Supports healthy aging of the brain
• Often used in biohacking stacks with agents like NAD⁺, methylene blue, and nootropics

Dosing and Administration

• Typical Protocol: 1–2 sprays per nostril, 1–2 times daily
• Cycle Duration: 5–10 days on, followed by a rest period or ongoing cycles as needed
• Onset: Effects may be felt within 30 minutes; cumulative benefits occur over 1–2 weeks
• Note: Best used under physician direction; adjust based on individual response

Safety and Tolerability

PE 22-28 is non-habit forming, non-stimulatory, and well-tolerated across most patient profiles. It has been used safely in both clinical and off-label settings in Russia and Eastern Europe for decades.

Reported side effects (rare and mild):

• Nasal irritation or dryness
• Temporary dizziness or headache
• Vivid dreams or increased mental clarity

Not recommended in:

• Pregnant or breastfeeding individuals
• Patients with active nasal infection or uncontrolled seizures

Storage and Handling

• Store refrigerated between 2°C–8°C (36°F–46°F)
• Do not freeze or expose to excessive heat or sunlight
• Ensure cap is secured tightly after each use
• Use within 30 days of opening for best potency

Why PE 22-28?

• Direct-to-brain delivery via nasal route—non-invasive and fast-acting
• Modulates BDNF and inflammation simultaneously, bridging neurology and immunology
• Ideal for neurorecovery, executive performance, and preventive brain aging
• Safe for cycling use, stacking, and integration into complex protocols

Summary

PE 22-28 Nasal Spray (20 mg) offers a precision-targeted solution for enhancing brain function, calming inflammation, and restoring cognitive energy. As a SEMAX compound, it leverages the best of neuropeptide science to support individuals facing neurological stress, mental fatigue, or performance demands. Whether used for recovery or peak productivity, PE 22-28 delivers advanced support for a resilient, high-functioning brain.