Description

Triple-Action Topical Cream for Hormonal Hair Loss, Scalp Stimulation, and Follicle Reactivation

This prescription-strength Minoxidil / Tretinoin / Spironolactone compounded cream provides a targeted, multi-mechanism solution for patients experiencing androgenetic alopecia (AGA) and hormonal scalp thinning. Designed to treat the vascular, hormonal, and cellular dysfunctions underlying hair loss, this cream formulation is ideal for those seeking a localized, non-systemic treatment option that addresses multiple causes of follicular miniaturization.

Unlike traditional over-the-counter hair loss products, this advanced formulation combines three pharmacologically active agents in a clinically optimized cream base, ensuring prolonged scalp contact, enhanced penetration, and superior tolerability, especially for individuals with sensitive or inflamed scalp conditions.

Key Benefits

• Stimulates follicular blood flow to extend the hair’s growth phase (anagen)

• Improves topical absorption and cellular turnover for increased efficacy

• Blocks local androgen activity (DHT) at the scalp without systemic hormonal impact

• Helps reduce inflammation, scalp buildup, and hormonal miniaturization

• Cream base provides precise application, minimal residue, and reduced irritation compared to liquid solutions

• Designed for daily, long-term use in both men and women under medical supervision

Active Ingredients & Mechanism of Action

Minoxidil (70 mg/g)
Minoxidil is a vasodilator that enhances microcirculation at the follicular level, supplying oxygen and nutrients to dormant or miniaturized hair follicles. By stimulating follicular potassium channels, Minoxidil extends the anagen phase of the hair cycle, encouraging the regrowth of thicker, healthier hair strands. At 7% strength (70 mg/g), it offers enhanced stimulation for patients who have not responded to standard 5% formulations.

Tretinoin (1.25 mg/g)
Tretinoin, a derivative of vitamin A (retinoic acid), increases cell turnover and epidermal permeability, improving the absorption of Minoxidil and other active agents. It also helps reduce scalp buildup and promotes a healthier environment for follicular function. Tretinoin has shown synergistic effects when combined with Minoxidil in clinical studies.

Spironolactone (5 mg/g)
Spironolactone acts as a local anti-androgen, blocking androgen receptors and inhibiting the effects of DHT at the scalp. This mechanism reduces hormonal-driven follicle shrinkage without the systemic risks of oral anti-androgens. Particularly beneficial in female pattern hair loss and hormonal shedding, topical Spironolactone offers a safe, localized approach to hormonal regulation.

Indications

This triple-action topical cream is ideal for treating:

• Androgenetic alopecia (male and female pattern hair loss)

• Hormonal hair thinning due to PCOS, menopause, or postpartum changes

• Frontal or temple hairline recession in women

• Early-stage hair loss and scalp miniaturization

• Patients intolerant of oral DHT blockers

• Adjunct therapy after PRP, transplant, or microneedling procedures

Directions for Use

1. Cleanse and dry the affected scalp area thoroughly.

2. Apply a pea-sized amount (approx. 1 gram) to areas of thinning or concern once daily.

3. Gently massage into the scalp until fully absorbed.

4. Do not rinse. Allow to absorb before applying other topical products.

5. Wash hands after application.

Use consistently for a minimum of 3–6 months for optimal results. Continue use to maintain gains.

What to Expect

• Weeks 1–4: Decreased shedding, improved scalp texture

• Weeks 4–8: Emergence of fine vellus hairs in treated areas

• Months 3–6: Thickening and pigmentation of regrowing hairs

• 6 Months+: Increased overall density, reduced scalp visibility, stabilized hairline

Mild shedding may occur initially as hair follicles reset and re-enter active growth.

Safety & Precautions

• For external use only

• Do not apply to broken, irritated, or infected skin

• Avoid contact with eyes, lips, or mucous membranes

• Not for use during pregnancy or breastfeeding

• Discontinue if persistent irritation, redness, or burning occurs

• Not intended for pediatric use unless prescribed by a physician

This formulation may cause mild dryness, tingling, or flaking in the first few weeks due to Tretinoin activity.

Storage Instructions

• Store at 15–25°C (59–77°F)

• Protect from direct sunlight and moisture

• Keep container tightly closed when not in use

• Keep out of reach of children

Ideal Patient Profile

This cream is well-suited for:

• Women with hormonally influenced hair thinning (e.g., PCOS, menopause)

• Men with early-stage AGA seeking a topical, multi-pathway treatment

• Individuals who cannot tolerate oral Finasteride or Spironolactone

• Patients with sensitive or reactive scalps needing a cream-based formulation

• Users seeking to combine DHT control, stimulation, and absorption enhancement in a single application

A Modern, Triple-Pathway Approach to Hair Regrowth

The Minoxidil / Tretinoin / Spironolactone topical cream is a next-generation, dermatologist-formulated solution designed to combat hair loss at its root causes. By delivering vascular, hormonal, and absorption-based mechanisms through a precision cream format, this product helps reactivate dormant follicles, prevent future thinning, and support sustained, visible improvement in scalp coverage and hair health.