Description

Targeted Local Antibiotic Therapy for Periodontal Applications
Packaging: 10 Boxes / 24 Cartridges per Box

Product Overview

Minocycline 1mg Microsphere Delivery System is a localized, controlled-release antibiotic treatment designed specifically for subgingival application in the management of periodontal disease. Utilizing an advanced bioresorbable microsphere technology, this formulation delivers sustained minocycline release directly into the periodontal pocket—targeting harmful pathogens while minimizing systemic exposure.

Each unit includes 10 boxes, with 24 single-dose cartridges per box, ideal for high-volume dental practices or clinical institutions focused on precision periodontal care. The cartridges are pre-loaded for direct application using compatible delivery systems, ensuring accuracy, sterility, and ease of use in chairside treatment settings.

Key Features

• Microsphere-Based Delivery Technology
  • Sustained release of minocycline over 14 days

  • Direct subgingival placement for localized efficacy

  • Bioresorbable microspheres eliminate need for removal

• Potent Antibiotic Action
  • Broad-spectrum coverage, especially effective against Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and other key periodontal pathogens

• Minimally Invasive
  • Non-surgical adjunct to scaling and root planing (SRP)

  • Improves treatment outcomes without systemic antibiotics

• Sterile, Pre-filled Cartridges
  • 24 cartridges per box, single-use

  • Designed for ease of use with standard applicators

  • Reduces preparation time and cross-contamination risk

Clinical Applications

This Minocycline 1mg delivery system is widely used by periodontists and general dentists as a highly effective adjunct to mechanical debridement in the treatment of:

• Chronic and aggressive periodontitis

• Sites with persistent bleeding on probing (BOP)

• Deep periodontal pockets ≥5mm

• Refractory periodontal cases

• Localized recurrence post-therapy

Mechanism of Action

Minocycline is a semi-synthetic tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. This results in bacteriostatic activity against a broad range of Gram-negative and Gram-positive organisms involved in periodontal infections.

The microsphere matrix is composed of bioresorbable polymers that allow for gradual drug release over 14 days, ensuring prolonged exposure of the bacteria to the antibiotic directly at the infection site.

Benefits for Dental Practices

• Improves SRP Outcomes: Enhances pocket depth reduction and clinical attachment gain when used with scaling and root planing

• Minimizes Antibiotic Resistance: By localizing drug delivery, systemic exposure is avoided, reducing the risk of systemic antibiotic resistance

• No Patient Compliance Needed: Unlike oral antibiotics, once administered, the therapy is complete—no pills, no missed doses

• Quick & Simple Application: Designed for seamless integration into standard periodontal protocols

Instructions for Use

1. Prepare the Pocket
   • Complete scaling and root planing (SRP) prior to application

   • Ensure the area is free of debris and relatively dry

2. Insert the Cartridge
   • Load the pre-filled cartridge into the compatible applicator

   • Gently insert the tip into the base of the periodontal pocket

3. Dispense the Microspheres
   • Slowly express the content to ensure complete coverage

   • Withdraw the applicator while dispensing to fill the pocket uniformly

4. Do Not Pack or Seal
   • No dressing or adhesive is required

   • Microspheres will remain in place and gradually resorb

Storage and Handling

• Store at 15°C to 25°C (59°F to 77°F)

• Avoid exposure to direct sunlight or excessive moisture

• Do not use if the seal is broken or past the expiration date

• Single-use cartridges—do not reuse or resterilize

Safety & Precautions

Contraindications:

• Known hypersensitivity to minocycline or other tetracyclines

• Pregnancy, breastfeeding, or patients under 8 years of age

Side Effects May Include:

• Mild irritation at the site of application

• Transient tooth discoloration (removable with polishing)

• Rare systemic absorption effects—consult physician if symptoms arise

Note: Avoid exposure to excessive UV or sunlight during treatment due to potential photosensitivity associated with tetracycline derivatives.

Who Can Benefit

• Dental Clinics & Periodontists: Increase success rate of non-surgical periodontal therapy

• Academic Institutions: Ideal for teaching advanced periodontal management

• Mobile Dental Units: Compact, sterile, and easy to administer on-site

• Group Practices: Economical multi-box packaging for high patient volumes

Enhanced Periodontal Treatment, Made Easy

The Minocycline 1mg Microsphere Delivery System brings precision and convenience to periodontal therapy. With its advanced formulation and professional packaging, it supports better clinical outcomes, improves patient satisfaction, and streamlines chairside workflow for every periodontal procedure.