Description

(Redox Modulator for Mitochondrial Health, Cognitive Function, and Oxidative Stress Support)

Precision Redox Therapy for Cellular Energy, Neurological Recovery, and Antioxidant Defense

Methylene Blue is a highly studied redox-active compound with a rich history in clinical medicine and a growing role in modern functional, integrative, and neurological therapies. This 10 mg/mL sterile injectable formulation in a 10 mL vial provides a convenient, controlled dosage suitable for IV infusion or research-based clinical protocols requiring enhanced mitochondrial support and oxidative modulation.

Originally developed as a dye and antimalarial, methylene blue is now used for its mitochondrial electron-shuttling properties, neuroprotective effects, and ability to reduce oxidative damage in cells. Its broad therapeutic potential has made it a versatile agent in treating metabolic fatigue, cognitive decline, chronic infections, and more.

Product Overview

• Concentration: 10 mg/mL

• Volume: 10 mL sterile vial

• Route of Administration: Intravenous infusion (diluted), as directed by a licensed professional

• Formulation: Preservative-free, USP-grade, sterile injectable solution

• Storage: Store at 15–25°C (59–77°F), protect from light

• Application: For use in clinical protocols under physician guidance

What Is Methylene Blue?

Methylene blue is a synthetic phenothiazine compound that acts as both a pro-oxidant and antioxidant, depending on the redox state of the tissue. It accepts and donates electrons within the electron transport chain (ETC), particularly when mitochondrial Complex I or IV function is impaired, thereby enhancing ATP production and cellular metabolism.

It has demonstrated benefits in multiple domains:

• Neurodegenerative disease support

• Chronic fatigue and mitochondrial dysfunction

• Post-viral syndromes (e.g., Long COVID)

• Mood regulation and cognitive clarity

• Adjunct in treatment of sepsis and shock

Mechanism of Action

Methylene blue works by:

• Bypassing impaired mitochondrial complexes to support energy production

• Enhancing oxidative phosphorylation and cellular respiration

• Neutralizing reactive oxygen species (ROS)

• Supporting NAD⁺ regeneration, essential for energy metabolism

• Inhibiting nitric oxide synthase and guanylate cyclase, reducing vasodilation in sepsis

• Modulating acetylcholine and monoamine oxidase activity, influencing cognitive performance and mood

This dual role makes it uniquely effective in mitochondrial stress states, neuroinflammation, and oxidative pathologies.

Clinical and Functional Applications

1. Mitochondrial Enhancement

• Increases ATP output in energy-deficient states

• Used in chronic fatigue, fibromyalgia, and neuroimmune syndromes

2. Neurological and Cognitive Support

• Enhances memory and focus

• Supports cognitive recovery post brain injury

• Adjunct in Alzheimer’s disease and Parkinson’s protocols (investigational use)

3. Oxidative Stress and Inflammation

• Reduces systemic oxidative load

• Improves resilience in infections, post-viral fatigue, and toxin exposure

4. Adjunct in Shock and Hypoxia

• Used in vasoplegic shock and refractory hypotension

• May enhance oxygen utilization and tissue perfusion

Dosing and Administration

• Standard dose: 0.5–2 mg/kg body weight, infused slowly over 30–60 minutes

• Dilution: Must be diluted in appropriate IV fluid (e.g., 100 mL saline or dextrose)

• Route: Intravenous (IV) infusion only

• Frequency: As clinically indicated by provider protocols

Note: Medical supervision is required. Inappropriate use or dosing may lead to adverse reactions.

Safety and Tolerability

Methylene blue is generally well tolerated at clinical doses when administered correctly. However, important safety considerations include:

Mild side effects may include:

• Blue-green discoloration of urine, stool, or skin

• Lightheadedness or mild headache

• Nausea (rare)

• Local irritation at injection site (if improperly diluted)

Serious precautions:

• Serotonin syndrome risk when combined with SSRIs, SNRIs, MAOIs, or other serotonergic agents

• Hemolytic risk in patients with G6PD deficiency – always screen before use

• Avoid in pregnancy and lactation unless medically justified

Storage Instructions

• Store at controlled room temperature (15–25°C)

• Keep in original amber vial to protect from light exposure

• Do not freeze or shake

• Use sterile transfer techniques; inspect for particulate before administration

Why Choose Methylene Blue Injection 10 mL?

• Compact and efficient format for precision dosing

• Sterile, preservative-free, and professionally compounded

• Backed by decades of clinical research in neurology, mitochondrial science, and redox biology

• Compatible with integrative IV protocols including NAD⁺, glutathione, and CoQ10

• Ideal for clinics specializing in chronic fatigue, cognitive therapy, and systemic rejuvenation

Summary

Methylene Blue Injection – 10 mg/mL, 10 mL Vial is a clinically versatile solution for supporting cellular metabolism, neurological clarity, and oxidative stress resilience. With precise dosing and powerful mitochondrial action, it stands at the intersection of functional medicine, regenerative health, and metabolic therapy. When administered by professionals, it offers a robust, well-tolerated tool to optimize cellular performance and restore energy from the inside out.