GHK-Cu Scalp Solution

Description

About GHK-Cu Scalp Solution

GHK (glycyl-L-histidyl-L-lysine) is a copper peptide found in human plasma that readily binds with copper, forming the complex GHK-Cu. Originally discovered in the 1970s, GHK-Cu has garnered attention for its potential protective and regenerative properties. GHK-Cu is widely used in hair product formulations due to its potential to stimulate hair follicles and promote hair thickness.[1]

Mechanisms of Action

GHK-Cu may support hair health by acting on several biological pathways in the scalp. It may stimulate the formation of new blood vessels around hair follicles by increasing vascular endothelial growth factor (VEGF) production, which may improve nutrient supply essential for hair growth. GHK-Cu may also prevent premature hair follicle regression by inhibiting transforming growth factor beta, potentially prolonging the hair growth phase. Additionally, it may support dermal papilla cells by promoting their growth and reducing cell death, which may help maintain and support hair follicles.[2]

Contraindications & Precautions

GHK-Cu formulations are generally well-tolerated; however, it is recommended that individuals with sensitive skin or scalp should perform a patch test prior to regular application. Users should discontinue use if they experience any signs of allergic reactions, such as redness, hives, or itchiness.[3] While copper can potentially cause skin irritation or toxicity, in vitro studies suggest that GHK-Cu complexes may have a lower likelihood of inducing these effects.[4] However, it is recommended to consult a healthcare professional before using any new product on the skin or scalp.

The use of GHK-Cu has not been established in pediatric, pregnant, and breastfeeding individuals.

Adverse Reactions / Side Effects

GHK-Cu appears to be well tolerated, with no known serious side effects reported.

Pregnancy & Breastfeeding

There is limited data on the safety of GHK-Cu during pregnancy. As a precaution, it is advisable to consult a healthcare provider before using this product.

There is limited data on the safety of GHK-Cu during breastfeeding. As a precaution, it is advisable to consult a healthcare provider before using this product.

Storage

Store this medication in its original container at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

References

Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018 Jul 7;19(7):1987. doi: 10.3390/ijms19071987.
Liu T, Liu Y, Zhao X, Zhang L, Wang W, Bai D, Liao Y, Wang Z, Wang M, Zhang J. Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application. Bioact Mater. 2023 Nov 1;32:502-513. doi: 10.1016/j.bioactmat.2023.10.002.
Copper Peptides in Skincare. Healthline. Available at: https://www.healthline.com/health/copper-peptides#drawbacks.- LinkOpens in New Tab
Li H, Toh PZ, Tan JY, Zin MT, Lee CY, Li B, Leolukman M, Bao H, Kang L. Selected Biomarkers Revealed Potential Skin Toxicity Caused by Certain Copper Compounds. Sci Rep. 2016 Nov 28;6:37664. doi: 10.1038/srep37664.