Description

(Topical Neuropathic Pain Management Cream)

Targeted Peripheral Nerve Relief Without Systemic Side Effects

Gabapentin 10% Cream (100 mg/g) offers localized, non-systemic relief for neuropathic pain and nerve-related skin discomfort. Compounded for topical application, this preparation is ideal for patients who suffer from postherpetic neuralgia, diabetic neuropathy, carpal tunnel syndrome, vulvodynia, or other forms of peripheral nerve pain, especially when oral medications are ineffective, contraindicated, or poorly tolerated.

Unlike systemic gabapentin, which requires titration and may cause central nervous system (CNS) side effects, this topical cream delivers active medication directly to affected areas, minimizing the risk of dizziness, drowsiness, or cognitive impairment. This 30-gram tube is convenient for daily use, typically applied to localized sites of pain or irritation as directed by a healthcare provider.

Key Benefits

• Contains gabapentin 10% (100 mg/g) for high-concentration topical delivery

• Provides targeted relief for localized nerve pain and sensitivity

• Avoids systemic exposure and associated side effects (e.g., sedation, dizziness)

• Well-suited for patients with diabetic neuropathy, neuralgia, or post-surgical nerve pain

• Can be used adjunctively with systemic medications or physical therapy

• Compounded in a USP-compliant pharmacy for purity and precision

• Supplied in a 30-gram tube or airless pump for ease of use

Mechanism of Action

Gabapentin is an analogue of gamma-aminobutyric acid (GABA) but does not act on GABA receptors. Instead, it binds to the α2δ subunit of voltage-gated calcium channels, reducing excitatory neurotransmitter release from overactive peripheral nerves. In topical use, it modulates localized hyperexcitability, offering relief in conditions such as:

• Burning, tingling, or electric shock-like sensations

• Allodynia (pain from non-painful stimuli)

• Hyperalgesia (heightened response to pain)

Because the action is localized to the application site, systemic absorption is negligible in most patients, improving safety and tolerability.

Clinical Applications

Gabapentin 10% Cream is frequently prescribed for:

• Postherpetic Neuralgia (PHN)

• Diabetic Peripheral Neuropathy (DPN)

• Vulvodynia and Pudendal Neuralgia

• Trigeminal Neuralgia (when applied externally)

• Chronic Low Back or Sciatic Pain (with neuropathic features)

• Post-surgical or post-traumatic nerve irritation

• Chemo-induced neuropathy

• Complex Regional Pain Syndrome (CRPS)

This formulation may also be used off-label in dermatologic pain syndromes or pelvic floor therapy under specialist supervision.

Advantages Over Oral Gabapentin

• Fewer CNS side effects (e.g., no drowsiness, dizziness, or memory issues)

• No need for titration or gradual dose escalation

• Faster onset of localized relief

• Safe for older adults, renal impairment, or polypharmacy cases

• Useful for patients who cannot tolerate oral therapy

Dosing and Administration

• Apply a small amount (pea-sized or as prescribed) to the affected area

• Use 2–3 times daily or as directed

• Massage gently into the skin until fully absorbed

• Wash hands thoroughly after use

• Effects may be noticeable within 30 minutes to a few days, depending on condition severity

Patient Experience

Patients commonly report:

• Reduction in burning and tingling within days of use

• Improved tolerance to touch and movement

• Better quality of life without sedative side effects

• Long-term symptom relief when used consistently and appropriately

Safety and Side Effects

Gabapentin topical cream is generally well tolerated. Possible side effects may include:

• Mild skin irritation or redness at application site

• Transient stinging or cooling sensation

• Rare allergic reactions in sensitive individuals

Systemic side effects are uncommon due to minimal transdermal absorption. However, it should not be applied to broken or infected skin, mucous membranes, or open wounds.

Contraindications

• Known allergy to gabapentin or cream base components

• Damaged or severely inflamed skin in treatment area

• Avoid contact with eyes, mouth, or genital mucosa (unless specifically directed)

Storage Instructions

• Store at controlled room temperature (15–25°C / 59–77°F)

• Keep container tightly closed

• Do not freeze

• Keep out of reach of children

Who Should Consider This Cream?

Gabapentin 10% Cream is ideal for:

• Patients with localized neuropathic pain who cannot take or tolerate oral gabapentin

• Older adults or individuals on multiple CNS-active medications

• Patients with renal dysfunction who are sensitive to systemic dosing

• Individuals looking for a non-opioid, non-systemic pain relief option

Gabapentin 10% Cream (100 mg/g) in a 30-gram formulation offers a safe, convenient, and effective solution for patients experiencing neuropathic pain in localized areas. It represents a modern, patient-centered approach to pain management—minimizing systemic exposure while delivering meaningful relief where it’s needed most.