Description

(Topical Therapy for Anal Fissures: Pain Relief and Enhanced Healing Support)

Advanced Topical Relief for Acute and Chronic Anal Fissures

This Fissure Preparation Ointment combines the clinically proven benefits of Nifedipine 0.5% and Lidocaine 3% to offer a comprehensive, non-invasive treatment for patients experiencing anal fissures. Formulated in a 60-gram prescription-strength topical ointment, this preparation provides both vasodilatory healing support and localized pain relief, offering a trusted option for conservative management before surgical interventions are considered.

Whether used for acute tearing, chronic fissures, or postpartum perianal discomfort, this compounded ointment helps patients regain comfort, reduce inflammation, and accelerate the healing of the fissured epithelium in the anal canal.

Product Overview

• Active Ingredients:
  • Nifedipine 0.5% – a calcium channel blocker that relaxes anal sphincter tone

  • Lidocaine 3% – a local anesthetic that provides immediate pain relief

• Base: Smooth, stable ointment formulated for mucosal application

• Total Volume: 60 grams

• Route of Administration: Topical perianal or intrarectal (as directed)

• Packaging: Dispensed in a pharmacy-grade tube or jar, based on prescriber preference

• Storage: Room temperature (20–25°C); avoid heat or freezing

• Use: Physician-directed compound for rectal therapy

How It Works

Nifedipine 0.5% – Facilitates Healing by Reducing Sphincter Pressure

Nifedipine works as a topical smooth muscle relaxant. It targets the internal anal sphincter, which often goes into spasm as a response to fissure pain and inflammation. This spasm restricts local blood flow, creating a cycle of poor oxygenation and delayed healing.

By relaxing the sphincter and improving local perfusion, Nifedipine promotes:

• Faster epithelial repair

• Decreased inflammatory pain

• Reduced risk of chronic fissure formation

Lidocaine 3% – Rapid and Sustained Pain Control

Lidocaine acts as a fast-onset, surface-level anesthetic, providing immediate relief from the sharp, stinging pain typical of anal fissures. Its mechanism—blocking sodium channels in nerve fibers—makes it ideal for controlling:

• Pain during or after bowel movements

• Irritation from wiping or prolonged sitting

• Discomfort during healing phases

Together, these agents address both the symptomatology and the underlying ischemic pathology of fissures, providing effective, non-surgical management.

Indications

This compounded ointment is commonly prescribed for:

• Acute anal fissures (first onset or post-trauma)

• Chronic fissures with hypertrophic margins or spasm

• Fissures secondary to constipation, IBS, or Crohn’s

• Postpartum anal tearing or perineal irritation

• Adjunct to stool softeners and conservative care

Especially suitable for patients who cannot tolerate nitroglycerin-based ointments due to systemic side effects (e.g., headache, dizziness).

Dosing and Administration

• Typical dose: Apply a pea-sized amount (approximately 0.5 mL) to the anal opening 2–3 times daily, especially after bowel movements and at bedtime

• Optional: May be applied internally using a gloved finger or applicator if instructed

• Course duration: Use for 2–6 weeks, based on provider instructions and symptom resolution

• Instructions: Clean and dry the area before each application; wash hands thoroughly after use

Use only as prescribed. Do not exceed recommended frequency or apply to broken skin unless directed.

Safety and Tolerability

This preparation is well tolerated and localized, minimizing systemic effects.

Possible side effects (rare and typically mild):

• Mild burning or tingling sensation on first application

• Skin irritation or rash (especially if overused)

• Headache (rare, more common in hypersensitive individuals)

• Local redness or swelling

Patients should discontinue use and contact their provider if signs of allergic reaction or worsening pain occur.

Contraindications

• Do not use in patients with known allergy to nifedipine, lidocaine, or amide anesthetics

• Not recommended for open bleeding wounds or infected fissures without physician oversight

• Caution in pregnant or breastfeeding patients—use only if benefits outweigh risks and prescribed by a healthcare provider

Storage Instructions

• Keep at controlled room temperature (68–77°F / 20–25°C)

• Avoid direct sunlight, excessive moisture, or freezing

• Keep container tightly closed when not in use

• Store out of reach of children and pets

• Check label for expiration date and beyond-use date (BUD)

Why Choose This Compounded Fissure Ointment?

• Combines clinically validated healing support and fast pain relief

• Non-invasive alternative to botulinum injection or surgical sphincterotomy

• Easy to apply, cost-effective, and safe for home use

• Preferred by patients with low tolerance to nitroglycerin-based options

• Used in both primary care and colorectal specialist protocols

Summary

Fissure Preparation – Nifedipine 0.5% / Lidocaine 3% Ointment (60g) offers a dual-action solution for managing anal fissures conservatively, without compromising on relief or repair. By simultaneously reducing sphincter tone and numbing local pain, this formulation accelerates healing and improves patient comfort. Trusted in both acute and chronic care settings, this compound supports patients seeking non-surgical, pharmacist-formulated rectal therapy with proven clinical value.