Description

(Topical Rectal Therapy for Anal Fissure Pain Relief and Healing)

Dual-Action Relief for Anal Fissures: Vasodilation + Local Anesthesia for Fast, Targeted Comfort

This compounded Fissure Preparation Ointment combines Nifedipine 0.5% and Lidocaine 3% to deliver a powerful, dual-mechanism approach to the treatment of acute and chronic anal fissures. Packaged in a 30-gram topical ointment, this formula provides both pain relief and vascular support to accelerate healing of the fissure site, restore sphincter tone, and reduce inflammation.

Formulated for rectal and perianal use, this prescription compound is widely recommended in colorectal surgery, gastroenterology, and primary care protocols as a first-line non-surgical therapy for patients with persistent anal discomfort, bleeding, or irritation due to fissures.

Product Overview

• Active Ingredients: 
  • Nifedipine 0.5% – A calcium channel blocker that relaxes internal anal sphincter tone and promotes blood flow 
  • Lidocaine 3% – A local anesthetic for rapid, localized pain relief 
• Base: Smooth, non-irritating ointment for rectal mucosa 
• Package Size: 30 grams 
• Route of Administration: Topical, perianal and/or intrarectal (using an applicator if prescribed) 
• Storage: Store at room temperature; avoid excessive heat or freezing 
• Use: Compounded prescription; for use under medical supervision 

How It Works

1. Nifedipine 0.5% – Sphincter Relaxation and Blood Flow Support

Nifedipine is a calcium channel blocker traditionally used for hypertension but increasingly employed topically in the treatment of anal fissures. It works by relaxing the internal anal sphincter, thereby reducing sphincter pressure and increasing local blood flow—a key factor in promoting healing of ischemic tissue at the fissure site.

Benefits include:

• Relief from ischemic pain 
• Enhanced wound perfusion to promote granulation and epithelialization 
• Reduced risk of recurrence from chronic sphincter tension 

2. Lidocaine 3% – Fast-Acting Local Anesthesia

Lidocaine provides immediate numbing relief from pain, burning, or itching commonly experienced with fissures. It works by blocking sodium channels in peripheral nerves, preventing pain signals from reaching the brain. At 3%, this formulation delivers a therapeutic dose without systemic absorption risks when used properly.

Together, these agents address both the underlying pathophysiology of fissures (sphincter hypertonicity and poor perfusion) and the symptom burden (sharp pain, burning, irritation), making it a first-line conservative treatment before considering surgical interventions.

Indications

This topical compounded ointment is clinically indicated for:

• Acute anal fissures 
• Chronic anal fissures, with or without associated sphincter spasm 
• Postpartum rectal tears or irritation 
• Painful bowel movements due to fissure-related inflammation 
• Preventative care in patients with a history of fissure recurrence 

It is frequently recommended as an alternative to compounded nitroglycerin-based therapies, which may cause headaches or systemic hypotension.

Dosing & Administration

• Application Area: Apply a small amount (pea-sized) to the anal verge and fissure site, typically 2–3 times daily or as directed 
• Optional: For internal fissures, use an applicator tip if provided 
• Duration: Most patients experience relief within 7–14 days, with a typical course lasting 3–6 weeks 
• Hygiene: Clean and dry the area gently before each application 

Important: Always follow medical guidance and discontinue if irritation worsens.

Safety & Tolerability

This compounded formulation is well tolerated by most patients. It is non-systemic when applied topically and minimizes common adverse effects associated with oral or systemic medications.

Potential side effects (rare and mild):

• Mild local irritation or burning during initial use 
• Rare allergic reaction (rash, swelling) 
• Temporary lightheadedness if applied excessively or near open wounds 

Patients with known allergies to nifedipine, lidocaine, or other amide anesthetics should not use this formulation.

Storage & Handling

• Store at controlled room temperature (20–25°C / 68–77°F) 
• Do not freeze 
• Keep cap tightly closed and out of reach of children 
• Use within the time frame indicated on the prescription label 

Why Choose This Fissure Preparation?

• Dual therapy: Relieves pain and accelerates healing 
• Non-surgical and easy to use at home 
• Proven effectiveness in reducing recurrence and avoiding sphincterotomy 
• Well tolerated and preferred by patients with headache sensitivity to nitroglycerin 
• Trusted in colorectal and GI specialty care for conservative fissure management 

Summary

Fissure Preparation – Nifedipine 0.5% / Lidocaine 3% Ointment (30g) offers effective, fast-acting relief for patients suffering from anal fissures. With its dual-action formula, it not only soothes discomfort but also addresses the root cause of impaired healing. Safe, non-invasive, and clinically trusted, this compounded solution is a first-line therapy for both acute and chronic fissure care.