Estradiol / Lidocaine Topical Cream – 60 gm

$60.00

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Description

(Dual-Action Hormonal and Anesthetic Relief for Vulvovaginal Discomfort)

Comprehensive Topical Therapy for Atrophic Vaginitis, GSM, and Vulvar Pain Syndromes

Estradiol/Lidocaine 60 gm Cream is a compounded, dual-action formulation that combines bioidentical estradiol, a naturally occurring estrogen, with lidocaine, a fast-acting local anesthetic. Designed for external vaginal and vulvar use, this cream targets the hormonal and sensory causes of discomfort associated with genitourinary syndrome of menopause (GSM), atrophic vaginitis, vulvodynia, and related conditions.

This 60-gram size is ideal for long-term use or for patients requiring larger treatment areas, ensuring adequate supply for ongoing maintenance therapy. The formulation provides both immediate soothing relief from burning, irritation, and pain, and long-term restoration of tissue integrity, elasticity, and hydration.

Key Benefits

  • Estradiol (bioidentical estrogen) regenerates thinning vulvovaginal tissues

  • Lidocaine provides immediate numbing relief from pain and hypersensitivity

  • Helps relieve dryness, irritation, itching, and painful intercourse (dyspareunia)

  • Non-systemic topical application minimizes systemic hormone exposure

  • Useful in postmenopausal, perimenopausal, and postpartum patients

  • Compounded in a USP-compliant sterile pharmacy

  • Convenient 60 gm supply for routine or extended therapy

Mechanism of Action

Estradiol

Estradiol promotes epithelial regeneration by:

  • Enhancing mucosal hydration, collagen production, and vascularization

  • Improving tissue elasticity and thickness

  • Reversing symptoms associated with estrogen deficiency such as atrophic vaginitis, labial thinning, and burning sensation

Localized use avoids the systemic peaks associated with oral estrogen, making it safer and more targeted for patients with vulvovaginal symptoms only.

Lidocaine

Lidocaine provides rapid pain relief by:

  • Blocking sodium ion channels in local nerve endings

  • Interrupting pain signal transmission from the surface to the brain

  • Offering temporary numbing within minutes of application

It is especially effective for vulvodynia, post-coital sensitivity, or tactile pain disorders.

Clinical Applications

This cream is typically used to manage:

  • Genitourinary Syndrome of Menopause (GSM)

  • Vulvodynia / Vestibulodynia

  • Atrophic Vaginitis (due to menopause, oophorectomy, chemotherapy, or postpartum changes)

  • Painful Intercourse (Dyspareunia)

  • External vaginal dryness, irritation, and inflammation

It may be prescribed alone or as part of a multi-modal treatment plan in collaboration with pelvic floor therapy, systemic HRT, or physical rehabilitation.

Who Can Benefit?

  • Women with estrogen deficiency experiencing genital dryness, burning, or thinning

  • Patients recovering from surgical menopause, cancer treatment, or childbirth

  • Individuals who cannot tolerate systemic hormone therapy

  • Patients with localized nerve hypersensitivity or sexual pain disorders

Directions for Use

  • Apply a small amount (as directed) to the external vaginal or vulvar area

  • Use once or twice daily, depending on severity and physician recommendation

  • Do not apply intravaginally unless specifically prescribed

  • Typically used over 4–8 weeks, with maintenance as needed

Monitoring & Safety

Although topical estradiol has limited systemic absorption, monitoring is still advised in patients with:

  • History of hormone-sensitive cancers

  • Abnormal vaginal bleeding

  • Endometrial hyperplasia

  • Systemic symptoms of estrogen exposure (e.g., breast tenderness)

Providers may monitor estradiol levels, pelvic exams, or pap smears as clinically indicated.

Side Effects

Mild and typically transient:

  • Temporary numbness, tingling, or cooling sensation (from lidocaine)

  • Mild irritation at application site

  • Breast tenderness or spotting (rare with topical estradiol)

Discontinue and consult provider if you experience persistent irritation, allergic reactions, or signs of systemic hormone effects.

Contraindications

  • Known hypersensitivity to lidocaine, estradiol, or any cream component

  • Active vaginal or vulvar infections

  • History of breast or estrogen-dependent cancer, unless medically cleared

  • Pregnancy or lactation, unless directed by a physician

Storage Instructions

  • Store at controlled room temperature: 15–25°C (59–77°F)

  • Keep container tightly closed

  • Protect from direct light and moisture

  • For external use only

Packaging & Dispensing

  • Supplied in 60 gm metered-dose pump or airless jar for hygienic dispensing

  • Also available in smaller (30 gm) or larger (90+ gm) sizes by prescription

Estradiol/Lidocaine 60 gm Cream offers a clinically effective, dual-benefit approach for restoring tissue health and alleviating pain in the most sensitive areas. Trusted by women’s health providers, it supports both symptom relief and healing, allowing patients to regain confidence, comfort, and intimacy.

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