Description

(Selective Estrogen Receptor Modulator – Non-Citrate Formulation)

Precision Hormonal Modulation for Male and Female Endocrine Support

Clomiphene 50 mg Capsule (Base Form) is a non-citrate variant of the well-established selective estrogen receptor modulator (SERM), formulated for precise, targeted hormonal regulation in men and women. Commonly used to manage male secondary hypogonadism and female ovulatory dysfunction, this version contains pure clomiphene base (not clomiphene citrate), enabling accurate dosing without the additional molecular weight contributed by citrate salts.

Clomiphene in its base form functions identically in terms of mechanism, but with a molecularly pure composition that allows for more consistent pharmacokinetics and direct milligram-to-milligram comparison. It is used by endocrinologists, fertility specialists, and hormone optimization clinics seeking high-purity oral SERM therapy for testosterone restoration, ovulation induction, and reproductive system rebalancing.

Key Features

• Contains 50 mg of Clomiphene (Base) per capsule

• Free of citrate salt — allowing for precise active drug delivery

• Oral non-steroidal compound for hormonal rebalancing

• Activates endogenous hormone pathways through pituitary stimulation

• Used off-label for male testosterone restoration and sperm production

• Trusted for ovulatory support in anovulatory infertility

• Compounded to meet USP standards for pharmaceutical quality

Mechanism of Action

Clomiphene is a selective estrogen receptor modulator (SERM) that binds to estrogen receptors in the hypothalamus and pituitary gland, acting as an estrogen antagonist in these regions. This blockade disrupts the brain’s perception of circulating estrogen, prompting it to release more gonadotropin-releasing hormone (GnRH).

GnRH triggers the pituitary to increase secretion of:

• Luteinizing Hormone (LH) – stimulates testosterone production in men and triggers ovulation in women

• Follicle-Stimulating Hormone (FSH) – promotes ovarian follicle development and spermatogenesis

By activating this feedback loop, clomiphene boosts natural reproductive hormone levels, offering a non-injectable, fertility-friendly alternative to exogenous hormone therapy.

Clinical Applications

In Men

Clomiphene base 50 mg capsules are widely used off-label to treat secondary hypogonadism, especially in:

• Younger men with low testosterone but intact gonadotropin function

• Men desiring fertility preservation while increasing testosterone

• Patients weaning off long-term exogenous testosterone therapy

Benefits include:

• Restoration of endogenous testosterone production

• Increased sperm count and quality

• Improved libido, energy, and mood

• Avoidance of testicular atrophy commonly seen with TRT

In Women

Clomiphene base is a first-line therapy for:

• Anovulatory or oligo-ovulatory infertility (e.g., PCOS)

• Timed intercourse or IUI fertility cycles

• Mild ovarian stimulation in natural cycle IVF

It is typically taken early in the menstrual cycle (Day 2–5) for 5 consecutive days, under close medical supervision with ultrasound monitoring.

Clinical Advantages

• Non-steroidal: No exogenous hormone suppression

• Fertility-preserving in both men and women

• Oral dosing: No injections required

• Can be used alone or alongside other fertility agents

• Well-tolerated and reversible upon discontinuation

• Ideal for individuals not ready for TRT or assisted reproduction

Dosing Guidelines

• Men: 25–50 mg daily or every other day

• Women: 50–150 mg/day for 5 days per cycle

Actual dosage must be individualized based on baseline hormone levels, treatment objectives, and patient response.

Monitoring Parameters

For safe and effective use, patients should be monitored for:

• Total and Free Testosterone

• LH/FSH levels

• Estradiol (E2)

• Semen analysis (men)

• Ovarian follicle tracking by ultrasound (women)

• Liver function tests, if used long-term

Side Effects

Most side effects are mild and reversible. They include:

In Men:

• Visual disturbances (rare)

• Mood swings

• Elevated estradiol (may require AI support)

• Headache or GI discomfort

In Women:

• Hot flashes

• Ovarian cysts or overstimulation

• Breast tenderness

• Multiple ovulation or pregnancy (increased twin rate)

Contraindications

• Pregnancy or nursing

• Liver disease

• Hormone-sensitive cancers

• Unexplained abnormal uterine bleeding (in women)

• Known allergy to clomiphene

Storage and Handling

• Store at room temperature (15–25°C / 59–77°F)

• Protect from heat, light, and moisture

• Keep out of reach of children

• Use only under the supervision of a licensed healthcare provider

Who Is It For?

• Men with secondary hypogonadism seeking testosterone restoration

• Women with irregular ovulation or PCOS-related infertility

• Patients who want to preserve fertility during hormone support

• Clinics offering custom fertility or hormone protocols

• Individuals transitioning off or avoiding traditional TRT

Clomiphene 50 mg (Base) offers a clean, direct approach to stimulating hormonal balance. Whether for male testosterone recovery or female fertility support, it provides a well-researched, reliable, and fertility-conscious alternative to exogenous hormone therapies.