Description

Advanced Vitamin D3 Therapy for Plaque Psoriasis and Chronic Skin Conditions

Calcitriol 0.5 mcg Topical Ointment is a prescription-grade dermatological treatment formulated for the management of mild to moderate plaque psoriasis and other chronic skin conditions involving inflammation, scaling, and abnormal keratinocyte proliferation. As a synthetic form of active vitamin D3, Calcitriol modulates the skin’s immune response and cell growth, helping to normalize epidermal function and reduce the formation of psoriatic plaques.

Developed for sensitive skin areas and daily use, this ointment provides targeted relief while maintaining skin integrity, minimizing irritation, and supporting long-term remission.

What Is Calcitriol?

Calcitriol is the hormonally active form of vitamin D3 (1,25-dihydroxycholecalciferol). When applied topically, it helps to regulate keratinocyte differentiation and proliferation—key factors in the formation of psoriatic plaques. Additionally, Calcitriol exhibits immunomodulatory and anti-inflammatory properties, making it suitable for treating inflammatory skin disorders without the use of corticosteroids.

At a concentration of 0.5 mcg per gram, this formulation delivers a potent therapeutic dose that is both effective and well-tolerated.

Key Benefits

• Reduces plaque thickness, scaling, and redness

• Normalizes skin cell turnover

• Non-steroidal and suitable for long-term use

• Well tolerated on sensitive areas like the face, neck, and flexural regions

• Can be used as a monotherapy or adjunctive treatment

Indications

This ointment is indicated for the topical treatment of mild to moderate plaque psoriasis in adults and children aged 18 and older. It is especially useful for:

• Psoriatic lesions on the face, neck, or skin folds (where corticosteroids may be too harsh)

• Maintenance therapy following corticosteroid treatment

• Patients seeking non-steroid alternatives due to skin thinning or steroid intolerance

• Long-term management of chronic, recurring psoriatic plaques

Mechanism of Action

In psoriasis, the skin cells (keratinocytes) grow at an accelerated rate, leading to thickened, scaly plaques. Calcitriol helps by:

• Suppressing overactive immune responses in the skin

• Slowing down excessive keratinocyte proliferation

• Promoting proper differentiation of skin cells

• Reducing cytokine production and local inflammation

Unlike corticosteroids, Calcitriol does not cause skin atrophy or systemic suppression of adrenal function, making it suitable for prolonged use in delicate areas.

Application Instructions

1. Gently cleanse the affected area and pat dry.

2. Apply a thin layer of the ointment to the affected skin twice daily (morning and evening) or as directed by a healthcare provider.

3. Rub in gently until fully absorbed.

4. Wash hands thoroughly after application unless treating the hands.

For optimal results, apply consistently and avoid washing the area immediately after application. Use only on intact skin and avoid use on the face, eyelids, or mucous membranes unless specifically advised by a physician.

Treatment Expectations

Improvement is often observed within 2 to 4 weeks, with maximum benefits typically seen by 8 weeks. Continued use helps prevent recurrence and maintain skin clarity.

Safety and Tolerability

Calcitriol 0.5 mcg ointment is generally well tolerated, even on sensitive skin. It is free from steroids, parabens, and artificial fragrances, reducing the risk of irritation or allergic response.

Common side effects (rare):

• Mild burning or stinging at the site of application

• Itching or redness

• Skin discomfort in areas of high sensitivity

Precautions:

• Avoid excessive sun exposure or artificial UV light during use

• Do not use in combination with other vitamin D medications without supervision

• Discontinue use if signs of irritation or allergic reaction occur

• Use caution in patients with known calcium metabolism disorders or vitamin D toxicity

There is a theoretical risk of elevated serum calcium levels with overuse; hence, avoid application over large body surface areas without physician guidance.

Storage Instructions

• Store at room temperature between 15°C to 25°C

• Keep tube tightly closed when not in use

• Do not freeze

• Keep out of reach of children

Who Should Use This Product?

This ointment is ideal for:

• Adults with localized plaque psoriasis

• Patients needing long-term, steroid-free therapy

• Individuals with sensitive skin prone to steroid-related side effects

• Those undergoing maintenance therapy after successful steroid use

• Users preferring a well-tolerated, evidence-based solution backed by clinical research

A Trusted Topical for Chronic Psoriasis Care

Calcitriol 0.5 mcg Topical Ointment offers a non-steroidal, well-tolerated, and effective alternative for managing plaque psoriasis. With its unique ability to normalize skin cell function and minimize immune overactivity, it serves as a cornerstone for safe, sustainable, and targeted therapy.

Whether used alone or as part of a broader dermatological treatment plan, Calcitriol ointment supports clear, calm, and comfortable skin—without compromising long-term safety.