Description

(Targeted Metabolic Modulator for Fat Loss, Energy Optimization, and Metabolic Support)

Advanced Cellular Metabolism Support Through NNMT Inhibition

5-Amino-1MQ (5-Amino-1-Methylquinolinium) is a small-molecule NNMT (Nicotinamide N-Methyltransferase) inhibitor known for its potential to boost cellular energy, promote fat loss, and enhance metabolic efficiency. Each capsule contains 50 mg of pure 5-Amino-1MQ, designed for once-daily or clinician-guided dosing in metabolic support regimens.

This compound has gained attention in integrative and performance medicine for its role in modulating nicotinamide metabolism, which can influence NAD⁺ levels, insulin sensitivity, energy expenditure, and adipogenesis. It may support weight management, fat mobilization, and overall metabolic health in individuals with metabolic dysfunction or in those seeking improved body composition and vitality.

What Is 5-Amino-1MQ?

5-Amino-1MQ is a novel NNMT inhibitor that works at the epigenetic level to regulate cellular energy pathways. NNMT is an enzyme that influences methylation processes and is involved in the regulation of nicotinamide and S-adenosylmethionine (SAM) pools. Overexpression of NNMT has been linked to obesity, insulin resistance, and impaired NAD⁺ metabolism.

By selectively inhibiting NNMT, 5-Amino-1MQ can reduce the methylation of nicotinamide, leading to increased intracellular NAD⁺ availability and enhanced metabolic activity.

Mechanism of Action

• Inhibits Nicotinamide N-Methyltransferase (NNMT)

• Increases intracellular nicotinamide and NAD⁺ levels

• Improves mitochondrial efficiency and energy metabolism

• Supports lipolysis and fat oxidation

• Reduces adipocyte (fat cell) growth and proliferation

• Modulates inflammatory pathways and insulin signaling

These effects may lead to enhanced fat metabolism, better blood sugar regulation, improved endurance, and a general increase in metabolic flexibility.

Clinical Applications

While human trials are limited and 5-Amino-1MQ is not FDA-approved as a therapeutic agent, its mechanism and early research suggest potential benefits in:

• Weight management and body recomposition

• Adiposity reduction and fat loss

• Insulin sensitivity improvement

• Metabolic syndrome support

• NAD⁺ optimization and anti-aging protocols

• Cellular energy and endurance enhancement

• Adjunct to exercise or caloric restriction protocols

It may be particularly relevant for individuals with stubborn fat loss resistance, age-related metabolic decline, or those using NAD⁺-supportive therapies like NMN or NR.

Dosing and Administration

• Standard Dose: 50 mg once daily or as directed by a licensed healthcare provider

• Route: Oral capsule

• Timing: Preferably taken in the morning with or without food

• Duration: Often used in 4–8 week cycles depending on clinical goals

Because 5-Amino-1MQ modulates key metabolic pathways, it is strongly recommended that patients be monitored by a practitioner, especially when used alongside other metabolic or NAD⁺ therapies.

Safety and Tolerability

Preclinical studies suggest that 5-Amino-1MQ is well-tolerated with a favorable safety profile. However, long-term human data is limited.

Reported or possible side effects (anecdotal):

• Mild gastrointestinal discomfort

• Temporary increase in energy or alertness

• Mild fluctuations in appetite or hydration

• Potential interactions with other metabolic regulators

Contraindications:

• Pregnant or breastfeeding individuals

• Patients with uncontrolled thyroid or adrenal disorders

• Individuals on insulin or glucose-lowering medications (unless medically supervised)

Storage and Handling

• Store in a cool, dry place at 15–25°C (59–77°F)

• Keep container tightly closed

• Protect from light and moisture

• Keep out of reach of children

• For compounded or research use only, as directed by a licensed healthcare provider

Why Choose 5-Amino-1MQ?

• Clinically relevant 50 mg strength

• High-purity pharmaceutical-grade compound

• Backed by preclinical metabolic science

• Integrates well with NAD⁺ optimization and fat-loss regimens

• No known hormonal effects; acts on epigenetic metabolism

• Used in functional, regenerative, and longevity-focused clinics

5-Amino-1MQ 50 mg offers a promising approach to modulating metabolism at the cellular and enzymatic level. By targeting the NNMT pathway, it helps restore metabolic balance, enhance energy, and potentially support sustainable fat loss without stimulants or hormonal interference. Ideal for use in personalized medicine, weight optimization protocols, and performance-focused wellness plans, 5-Amino-1MQ represents a cutting-edge advancement in metabolic support.