Description

(Neuroactive Peptide for Sexual Arousal and Libido Enhancement – Fast-Acting Nasal Form)

Non-Invasive Central Arousal Therapy for Men and Women

Bremelanotide (PT-141) is a neuropeptide developed to enhance sexual desire and arousal by acting directly on the central nervous system. This nasal spray formulation—5 mg/mL in a 10 mL bottle—offers a needle-free, fast-absorbing alternative to injectable forms of PT-141, delivering reliable, rapid-onset support for low libido, hypoactive sexual desire disorder (HSDD), and arousal dysfunction in both men and women.

Unlike PDE5 inhibitors, Bremelanotide does not act on the vascular system directly. Instead, it stimulates melanocortin receptors in the hypothalamus, helping initiate and sustain sexual desire and arousal—even when physical dysfunction or psychological inhibition are present.

Product Overview

• Active Ingredient: Bremelanotide (PT-141)

• Concentration: 5 mg/mL

• Total Volume: 10 mL nasal spray bottle

• Formulation: Sterile, preservative-free aqueous nasal solution

• Administration: Intranasal spray (self-administered)

• Storage: Store refrigerated at 2–8°C (36–46°F); do not freeze

• Use: Physician-supervised therapy for sexual dysfunction and arousal enhancement

What Is Bremelanotide?

Bremelanotide is a synthetic melanocortin receptor agonist, specifically targeting MC4R (melanocortin 4 receptors) in the hypothalamus. It was initially investigated as a tanning agent (related to melanotan II), but researchers discovered its profound effects on libido and sexual behavior in both men and women.

Unlike common ED medications, which primarily increase genital blood flow, Bremelanotide works by activating neural pathways that govern sexual motivation and response. This makes it highly effective even when the root cause is hormonal imbalance, psychological stress, fatigue, or age-related decline.

Mechanism of Action

• Stimulates melanocortin receptors in the central nervous system

• Triggers dopaminergic pathways that control sexual desire and arousal

• Enhances readiness for intimacy without needing sexual stimulation beforehand

• Intranasal delivery bypasses the digestive tract for fast systemic absorption

• Onset of action: approximately 15–30 minutes

• Duration of effects: typically 4–8 hours

Clinical Indications

This nasal spray is used to treat or support:

• Hypoactive Sexual Desire Disorder (HSDD) in pre- and postmenopausal women

• Sexual arousal difficulties in men and women

• Erectile dysfunction (ED) with a psychological or neurogenic basis

• Libido decline related to aging, stress, SSRIs, or hormonal therapy

• Performance anxiety and intimacy issues in otherwise healthy individuals

PT-141 nasal spray is especially useful for individuals who prefer non-injectable options and desire discreet, self-directed use.

Dosing and Administration

• Typical Dose: 1.25 mg to 2 mg (0.25–0.4 mL) per dose

• Administration: Intranasal spray in one or both nostrils, as directed

• Timing: Use 15–30 minutes before anticipated sexual activity

• Frequency: No more than 1 dose per 24-hour period; maximum 8 doses/month recommended

• Instructions: Gently shake the bottle, prime before first use, and avoid blowing nose immediately after administration

Dosing can be adjusted based on individual response and tolerability.

Benefits of Nasal Delivery

• Non-invasive alternative to injections

• Faster absorption through the nasal mucosa

• Ideal for those uncomfortable with needles

• Discreet and travel-friendly

• Allows for on-demand, user-controlled dosing

Safety and Tolerability

Bremelanotide is generally well tolerated, with the nasal formulation offering comparable efficacy to injectable routes.

Common, mild side effects may include:

• Nasal congestion, irritation, or mild stinging

• Nausea or flushing (usually dose-related and transient)

• Headache or fatigue

• Slight increase in blood pressure (temporary; monitor if hypertensive)

No sexual adverse effects like priapism or tachyphylaxis have been reported in clinical trials at standard doses.

Contraindications

Do not use in:

• Individuals with uncontrolled high blood pressure or cardiovascular disease

• Known hypersensitivity to melanocortin peptides

• Pregnant or breastfeeding individuals (safety not established)

• Concurrent use with medications that affect blood pressure or CNS stimulants

Storage and Handling

• Store in a refrigerator (2–8°C / 36–46°F)

• Do not freeze

• Use within 30 days of opening or as directed by your pharmacist

• Keep nozzle clean and replace cap securely after each use

Why Choose Bremelanotide Nasal Spray?

• Central nervous system action = enhanced arousal independent of vascular dysfunction

• Safe and effective in both men and women

• Convenient needle-free formulation for on-demand use

• Ideal for HSDD, arousal disorders, or psychogenic ED

• Strong safety record across clinical trials and compounding pharmacy use

Summary

Bremelanotide (PT-141) Nasal Spray – 5 mg/mL, 10 mL offers a fast-acting, non-invasive solution for individuals seeking to restore or enhance sexual desire, arousal, and intimacy connection. Whether managing a diagnosed condition or looking to revitalize sexual wellness, this formulation provides a discreet, effective option backed by neuroscientific research and clinical efficacy.