Description

(Multi-Action Topical Ointment for Anal Itching, Inflammation, and Skin Protection)

Advanced Topical Relief for Persistent Anal Itch and Inflammation

This 60-gram compounded Pruritus Ani Ointment delivers a uniquely effective combination of Hydrocortisone 2%, Iodoquinol 1%, Metronidazole 10%, and Zinc Oxide 2%, providing multi-layered relief for patients suffering from pruritus ani—a chronic and often distressing condition characterized by anal itching, irritation, and inflammation.

This formula is designed to address the underlying causes of inflammation and microbial imbalance, while simultaneously soothing and protecting delicate perianal skin. It is suitable for both short-term flare-ups and longer treatment courses, depending on the underlying cause and clinical judgment.

Product Overview

• Active Ingredients:
  • Hydrocortisone 2% – Anti-inflammatory corticosteroid

  • Iodoquinol 1% – Antibacterial and antifungal agent

  • Metronidazole 10% – Antimicrobial and anti-inflammatory

  • Zinc Oxide 2% – Skin barrier protectant and mild antiseptic

• Form: Compounded ointment, optimized for mucosal and perianal skin

• Volume: 60 grams

• Route: External topical application only

• Storage: Room temperature (20–25°C); avoid excess heat and moisture

• Prescription Required: Custom-compounded by pharmacy based on clinical evaluation

Mechanism of Action

This ointment provides relief by acting on multiple key pathologies contributing to pruritus ani:

1. Hydrocortisone 2% – Inflammation Reduction

Hydrocortisone suppresses local inflammatory responses by inhibiting cytokine production and decreasing vascular permeability. This helps reduce:

• Swelling

• Redness

• Chronic itching

2. Iodoquinol 1% – Antimicrobial Defense

Iodoquinol acts as a broad-spectrum antimicrobial, especially against fungi and gram-positive organisms often found in perianal colonization. It also exhibits mild anti-inflammatory and antipruritic properties.

3. Metronidazole 10% – Anaerobic Bacterial and ROS Control

Metronidazole, commonly used off-label in dermatologic settings, helps eliminate anaerobic bacteria and reduce oxidative stress in the skin. It plays a key role in:

• Managing perianal microbial imbalances

• Reducing inflammatory free radicals

• Supporting remission in recalcitrant pruritus ani

4. Zinc Oxide 2% – Protective Barrier and Calming Agent

Zinc oxide provides mechanical protection against moisture, friction, and irritants. It also:

• Soothes irritated skin

• Promotes epidermal healing

• Reduces local irritation from stool, sweat, or topical allergens

Clinical Use and Indications

This compounded formula is appropriate for:

• Chronic pruritus ani (idiopathic or secondary)

• Post-inflammatory skin damage in the perianal area

• Moisture-related maceration

• Suspected yeast or anaerobic colonization

• Recovery from eczema or contact dermatitis in perirectal tissues

It is especially effective for patients who have failed monotherapy with over-the-counter or single-agent prescription creams.

Dosage and Administration

• Frequency: Apply a thin layer to clean, dry skin 2–3 times daily or as directed

• Best use: After bowel movements and before bed

• Duration: Use for 7–21 days, or until resolution of symptoms

• Hygiene: Gently cleanse with water (avoid harsh soaps) before each application

• Caution: Do not occlude the area unless advised by your healthcare provider

Patients should avoid rubbing or scratching to reduce trauma and prolong barrier integrity.

Safety and Tolerability

This formulation is well tolerated, particularly for localized and short-term use.

Possible mild side effects:

• Transient burning or stinging upon application

• Mild skin dryness or flaking

• Rare hypersensitivity reactions (redness, itching)

Extended use of topical corticosteroids may lead to epidermal thinning, so therapy duration should be monitored closely.

Contraindications

Do not use in:

• Patients with known allergies to any active ingredient

• Cases of untreated fungal or viral infections in the area

• Deep open wounds or ulcerations (unless directed)

• Pregnant or breastfeeding individuals, unless prescribed and monitored

Storage Instructions

• Store at room temperature (68–77°F / 20–25°C)

• Keep container sealed and away from direct sunlight

• Use within the pharmacy-assigned beyond-use date (BUD)

• Do not share; for single-patient use only

Why Choose This 60g Pruritus Ani Preparation?

• Combines anti-inflammatory, antimicrobial, and barrier-repair agents

• Larger volume ideal for extended therapy or bilateral involvement

• Tailored for perianal skin physiology

• Reduces the need for multiple over-the-counter treatments

• Trusted in colorectal, dermatology, and GI specialty settings

Summary

Pruritus Ani Preparation – Hydrocortisone 2% / Iodoquinol 1% / Metronidazole 10% / Zinc Oxide 2% (60g Ointment) is a pharmacist-compounded, physician-directed formulation crafted to relieve persistent anal itching, inflammation, and skin irritation. Designed for comprehensive, localized relief, this preparation addresses both symptoms and potential underlying microbial causes, making it a cornerstone of modern pruritus ani management protocols.