Description

(Neuro-Regenerative Peptide for Inflammation Modulation, Immune Support, and CNS Protection)

A Neuroprotective and Immunomodulatory Peptide for Stress Resilience and Inflammation Control

Met-Enkephalin, also referred to as opioid growth factor (OGF) or SEMAGlutide-analog compound, is a naturally occurring pentapeptide involved in the regulation of pain perception, immune function, and cellular regeneration. This 10 mg lyophilized peptide vial is intended for reconstitution with 5 mL bacteriostatic water, yielding a concentration suitable for subcutaneous or intranasal administration under medical supervision.

Best known for its neuroprotective and anti-inflammatory effects, Met-Enkephalin is used in advanced longevity, neurological, and immunological protocols. It has been studied for its influence on cancer biology, autoimmune response, and central nervous system recovery, particularly in conditions where stress modulation and cellular protection are therapeutic priorities.

Product Overview

• Active Ingredient: Met-Enkephalin (synthetic)

• Strength: 10 mg lyophilized powder per vial

• Reconstitution: 5 mL bacteriostatic water (final concentration: 2 mg/mL)

• Administration: Subcutaneous injection or intranasal delivery

• Storage (Unreconstituted): Refrigerate at 2–8°C (36–46°F)

• Storage (After Reconstitution): Refrigerate and use within 30 days

• Use: Professional use in peptide therapy, neuroimmune modulation

What Is Met-Enkephalin?

Met-Enkephalin is a naturally occurring endogenous opioid peptide composed of five amino acids: Tyr-Gly-Gly-Phe-Met. It belongs to the enkephalin family of peptides and functions both as a pain modulator and as a cell growth regulator, particularly within the immune system and nervous system.

Unlike exogenous opioids, Met-Enkephalin does not act as a narcotic. Instead, it stimulates specific opioid growth factor receptors (OGFr) and enhances tissue homeostasis, anti-inflammatory response, and neuro-regeneration without dependence or euphoria.

It is often associated with the peptide SEMAX and Selank because of overlapping neurotropic effects, including stress resistance, mood stabilization, and cognitive support.

Mechanism of Action

Met-Enkephalin acts on both delta-opioid receptors and OGFr, regulating pain signaling, immune surveillance, and cellular proliferation. Its biological effects include:

• Modulation of immune cell activity, particularly in T-cells and macrophages

• Inhibition of inflammatory cytokines like TNF-α and IL-6

• Regulation of cell growth in neoplastic and autoimmune conditions

• Neuroprotective support during hypoxic, ischemic, or oxidative stress

• Reduction of reactive oxygen species (ROS) and lipid peroxidation in neural tissue

• Enhancement of brain-derived neurotrophic factor (BDNF) expression (indirectly)

Clinical and Functional Applications

1. Neuroinflammation & Brain Health

• May help reduce microglial overactivity

• Used in recovery from brain injury, neurodegeneration, or long-COVID neurological symptoms

• Supports focus, clarity, and central stress reduction

2. Autoimmune & Inflammatory Conditions

• Modulates immune overactivation in chronic inflammation

• Investigated in Crohn’s disease, multiple sclerosis, and inflammatory bowel disorders

3. Oncology and Cell Cycle Regulation (Investigational Use)

• Inhibits proliferation of certain tumor cell lines via OGFr interaction

• Under study for its potential to suppress cancer-related inflammation

4. Longevity & Stress Support

• Supports systemic resilience against physiological and psychological stressors

• Often used alongside other nootropic peptides (e.g., Semax, Selank)

Dosing and Administration

• Typical dose: 200–500 mcg once or twice daily

• Administration: Subcutaneous injection or intranasal application

• Cycle duration: 4–8 weeks, depending on protocol

• Use with sterile technique if injecting

Note: Medical guidance is required for off-label or combination use.

Safety and Tolerability

Met-Enkephalin is well-tolerated, with low risk of side effects or toxicity due to its natural occurrence in the body. It is non-addictive, non-hormonal, and non-sedating.

Possible mild effects:

• Temporary fatigue or headache

• Injection site irritation (if SC route used)

• Mild nasal irritation (if intranasal)

It does not impair cognition or motor function and may improve stress tolerance and alertness in many individuals.

Contraindications

Do not use if:

• You have active or progressing cancer without physician supervision

• You are pregnant or breastfeeding

• You have an opioid allergy or are on conflicting immunosuppressants

Caution should be exercised when combining with other strong immune modulators.

Storage Instructions

• Before reconstitution: Store in refrigerator between 2–8°C

• After reconstitution: Use within 30 days, keep refrigerated

• Avoid direct sunlight, heat, or freezing

• Always use sterile equipment and avoid cross-contamination

Why Choose Met-Enkephalin?

• Endogenous peptide with targeted immune and neurological benefits

• Safe and effective in protocols addressing inflammation, fatigue, and neural recovery

• Used in longevity, brain health, and autoimmune modulation programs

• Can be stacked with BPC-157, TB-500, or Semax for comprehensive neuroimmune support

Summary

Met-Enkephalin 10 mg Vial (Reconstituted to 5 mL at 2 mg/mL) provides a targeted, non-opioid pathway for supporting immune balance, neuroprotection, and inflammatory control. As part of a broader functional medicine protocol, it offers immense potential for restoring gut-brain health, reducing chronic inflammation, and improving resilience in high-stress or chronic illness states.