Description

(Tight Junction Regulator for Gut Barrier Integrity, Leaky Gut, and Immune Support)

Targeted Gut Repair for Intestinal Barrier Protection and Inflammatory Control

Larazotide acetate is an investigational peptide therapy designed to restore gut barrier function by regulating tight junctions in the epithelial lining of the gastrointestinal (GI) tract. Offered in a 0.5 mg oral capsule formulation, this 90-count supply supports clinical protocols aimed at managing leaky gut syndrome (intestinal permeability), chronic inflammation, autoimmune reactivity, and digestive health optimization.

Commonly referred to as a “BPC for the gut,” Larazotide works by modulating the zonulin pathway, which governs the permeability of the intestinal epithelium. It is one of the few agents with direct action on paracellular tight junctions, making it a unique therapeutic option in functional medicine, gastroenterology, and integrative care.

Product Overview

• Active Ingredient: Larazotide acetate (synthetic octapeptide) 
• Strength: 0.5 mg per capsule 
• Capsules per Bottle: 90 
• Route of Administration: Oral 
• Use: Physician-directed gut support therapy 
• Storage: Store at room temperature; keep in a cool, dry place away from direct light 

What Is Larazotide?

Larazotide is a tight junction modulator developed as a peptide-based intervention for intestinal barrier dysfunction, most notably in conditions like celiac disease, IBD, and non-celiac gluten sensitivity. By reducing abnormal intestinal permeability, it limits the translocation of inflammatory triggers like bacterial endotoxins (LPS), gluten peptides, and undigested food proteins into systemic circulation.

While structurally unrelated to BPC-157, Larazotide provides comparable benefits in epithelial healing, mucosal protection, and immune regulation within the GI tract—earning it the reputation as a “gut-focused peptide” with advanced therapeutic promise.

Mechanism of Action

Larazotide acts by inhibiting the zonulin signaling pathway, a key regulator of tight junction proteins between intestinal epithelial cells. When zonulin levels are elevated—due to stress, infection, gluten, or inflammation—tight junctions loosen, allowing harmful substances to leak into the bloodstream.

By modulating this pathway, Larazotide:

• Restores tight junction integrity 
• Prevents antigenic and toxin translocation into systemic circulation 
• Reduces mucosal immune activation and systemic inflammation 
• Improves epithelial cell signaling and nutrient absorption 
• Supports homeostasis of gut microbiota and barrier function 

Clinical and Functional Applications

Larazotide 0.5 mg capsules are used in clinical settings for:

1. Leaky Gut Syndrome (Increased Intestinal Permeability)

• Reduces permeability caused by gluten, toxins, infections, or chronic stress 
• Enhances gut barrier resilience and tight junction cohesion 

2. Celiac Disease & Gluten Sensitivity

• Used as an adjunct to gluten-free diet protocols 
• Reduces immune reactivity to trace gluten exposure 
• Aids in mucosal healing during dietary transitions 

3. Autoimmune Conditions & Inflammation

• Limits systemic inflammation by reducing gut-derived immune triggers 
• Helpful in conditions like Hashimoto’s, rheumatoid arthritis, psoriasis, and lupus 

4. IBS, IBD, and GI Disorders

• Supports gut lining repair in Crohn’s, ulcerative colitis, and IBS 
• Reduces bloating, food sensitivities, and post-prandial discomfort 

5. Post-Antibiotic and Gut Reset Protocols

• Used as part of microbiome restoration programs 
• Reestablishes gut barrier protection after dysbiosis or medication use 

Dosing and Administration

• Typical dose: 0.5 mg taken orally three times daily, 15–30 minutes before meals 
• Duration: 8–12 weeks per cycle or as directed by your healthcare provider 
• Best results when combined with anti-inflammatory diet, microbiome support, and lifestyle modulation 

Safety and Tolerability

Larazotide is non-systemic and acts locally within the GI tract. It is well-tolerated and does not alter the absorption of nutrients, medications, or probiotics.

Possible mild side effects may include:

• Gastrointestinal discomfort (rare) 
• Headache or fatigue in sensitive individuals 
• Temporary bloating in early stages of barrier repair 

It is non-hormonal, non-immune suppressive, and non-stimulatory.

Contraindications and Precautions

Do not use if:

• You have an allergy to any peptide components 
• You are pregnant or nursing without physician approval 
• You have severe GI obstruction or active GI bleeding 

Always consult your physician before initiating therapy, especially if you are on immunomodulators or corticosteroids.

Why Choose Larazotide?

• One of the few tight junction–specific therapies available 
• Clinically validated in celiac disease and intestinal permeability models 
• Compatible with probiotics, BPC-157, glutamine, and other gut-repair agents 
• Non-systemic and safe for long-term use 

Summary

Larazotide 0.5 mg Capsules – 90 Count offers a novel, targeted approach to restoring gut barrier function, managing intestinal permeability, and supporting recovery from chronic inflammation and immune dysregulation. As part of a comprehensive gut-healing protocol, Larazotide can help seal the gut, reduce reactivity, and optimize digestive wellness from the inside out.