Description

(Hormonal and Anesthetic Combination for Vaginal and Vulvar Comfort)

Targeted Relief for Atrophic Vaginitis, Vulvodynia, and Genitourinary Syndrome of Menopause (GSM)

Estradiol/Lidocaine 30 gm Cream is a compounded topical formulation that combines bioidentical estradiol (a natural form of estrogen) with lidocaine, a local anesthetic, to address hormonal deficiency and pain in the vulvovaginal area. This combination is particularly effective in postmenopausal women or those experiencing estrogen deficiency-related symptoms, offering both tissue regeneration and soothing pain relief in a single, easy-to-apply formulation.

Formulated by licensed compounding pharmacies, this preparation supports urogenital tissue health, sexual function, and comfort, making it a preferred option for managing vaginal dryness, irritation, burning, dyspareunia (painful intercourse), and vulvodynia.

Key Features

• Contains Estradiol: A bioidentical estrogen that restores thinning mucosa 
• Includes Lidocaine: A fast-acting local anesthetic for immediate symptom relief 
• Topical, localized delivery: Minimizes systemic absorption 
• Provides both hormonal and sensory relief in one formulation 
• Non-invasive, non-systemic alternative to oral or injectable hormone therapy 
• Suitable for perimenopausal, menopausal, and postpartum women 
• Custom-compounded in 30 gm metered-dose dispensers or jars 

Mechanism of Action

Estradiol

Estradiol is the primary natural estrogen produced by the ovaries. In topical applications, it:

• Restores epithelial integrity in the vaginal and vulvar areas 
• Increases collagen synthesis, vascularization, and mucosal moisture 
• Reduces inflammation, thinning, and tissue fragility 
• Reverses symptoms of atrophic vaginitis and genitourinary syndrome of menopause (GSM) 

Estradiol acts locally on estrogen receptors in the vaginal and vulvar tissues, with minimal systemic absorption when applied externally, especially in low doses.

Lidocaine

Lidocaine is a well-known topical anesthetic that works by:

• Blocking sodium channels in peripheral nerve endings 
• Interrupting pain signals at the local level 
• Reducing burning, itching, and surface irritation almost immediately after application 

The combination of estradiol and lidocaine is particularly beneficial in patients who experience discomfort during intercourse or localized hypersensitivity, offering both long-term healing and short-term pain control.

Clinical Indications

This formulation is commonly prescribed for:

• Genitourinary Syndrome of Menopause (GSM) 
• Vulvodynia and Vestibulodynia 
• Vaginal atrophy (due to menopause, postpartum, or surgical menopause) 
• Painful intercourse (dyspareunia) 
• External vaginal irritation, dryness, or hypersensitivity 

Patient Benefits

• Improved vaginal comfort and elasticity 
• Increased lubrication and reduced dryness 
• Relief from burning, stinging, and irritation 
• Restoration of healthy vulvar skin tone and texture 
• Reduced pain during sexual activity or physical touch 
• Non-systemic hormone delivery suitable for localized treatment 

Dosing and Application

• Apply a pea-sized amount (or as directed) to the affected area 1–2 times daily 
• For use on external vulvar tissue only unless otherwise directed by the prescriber 
• Should be used consistently for 2–8 weeks for full therapeutic effect 
• Always follow provider instructions for duration, tapering, and monitoring 

Safety and Monitoring

While topical estradiol has minimal systemic absorption, patients should still be monitored for:

• Hormone-sensitive cancer history 
• Unexpected vaginal bleeding 
• Endometrial or breast changes 
• Any signs of systemic estrogen exposure, especially in long-term or high-dose use 

Routine follow-ups and pelvic exams are recommended during extended use.

Possible Side Effects

Estradiol-related (rare in topical form):

• Breast tenderness 
• Mild cramping 
• Nausea 
• Headache 

Lidocaine-related (rare with appropriate use):

• Mild skin numbness or tingling 
• Temporary stinging upon application 
• Local allergic reactions (redness or rash) 

Discontinue use and consult your healthcare provider if symptoms persist or worsen.

Contraindications

• History of breast, uterine, or estrogen-dependent cancer 
• Active vaginal infection or genital skin ulceration 
• Known allergy to lidocaine or local anesthetics 
• Pregnancy or breastfeeding unless under explicit medical guidance 

Storage Instructions

• Store at room temperature (15–25°C / 59–77°F) 
• Keep away from moisture and direct sunlight 
• Keep container tightly closed when not in use 
• For external use only 

Who Should Consider This Product?

This combination is ideal for:

• Women suffering from postmenopausal vaginal atrophy or pain 
• Patients with vulvodynia seeking a dual-action formula 
• Individuals who want to avoid systemic hormone therapy 
• Patients undergoing perimenopausal hormone transitions 
• Survivors of chemotherapy or surgical menopause (with physician approval) 

Estradiol/Lidocaine 30 gm Cream is a clinically balanced, targeted solution that addresses both the underlying hormonal deficiency and surface-level pain associated with vulvovaginal disorders. It delivers a unique dual benefit—restoring tissue health while providing immediate comfort, making it a trusted option for patients and providers alike.