Description

(Oral Combination Therapy for Testosterone Restoration with Estrogen Control)

A Dual-Action Hormonal Modulation Solution for Men with Secondary Hypogonadism

Enclomiphene/Anastrozole Capsules combine two well-established agents in male hormone optimization—Enclomiphene Citrate, a selective estrogen receptor modulator (SERM), and Anastrozole, a potent aromatase inhibitor (AI). Together, they offer a synergistic, non-steroidal strategy for restoring natural testosterone production while managing estradiol levels, making them especially useful for men suffering from secondary hypogonadism or recovering from testosterone suppression.

Formulated for oral administration, this compounded capsule is designed to stimulate the hypothalamic-pituitary-gonadal (HPG) axis while simultaneously preventing estrogen-related side effects such as gynecomastia, fatigue, water retention, or mood instability. It is a preferred solution for men seeking fertility-preserving testosterone support, either as an alternative to TRT or as part of post-cycle therapy (PCT).

Key Features

• Contains a combination of Enclomiphene Citrate (SERM) and Anastrozole (AI)

• Stimulates endogenous testosterone via increased LH and FSH

• Controls estrogen (estradiol) levels to prevent imbalances

• Maintains spermatogenesis and testicular volume

• Oral dosing – no injections or topical preparations

• Compounded in USP <795>/<797> compliant facilities

• Supports hormonal balance and fertility preservation

What Is Enclomiphene?

Enclomiphene citrate is the purified, trans-isomer of clomiphene citrate, known for its anti-estrogenic effects on the hypothalamus. It works by blocking estrogen receptors in the brain, leading to an increase in GnRH (gonadotropin-releasing hormone) release and subsequent rise in LH (luteinizing hormone) and FSH (follicle-stimulating hormone)—both necessary for testosterone production and sperm development.

Unlike exogenous testosterone, which suppresses natural hormone pathways, enclomiphene helps restore hormonal function from within.

What Is Anastrozole?

Anastrozole is an aromatase inhibitor that prevents the conversion of testosterone into estradiol. While enclomiphene increases testosterone levels, it may also elevate estrogen as a byproduct. Anastrozole counteracts this by lowering circulating estrogen, helping prevent:

• Gynecomastia (male breast tissue development)

• Emotional lability or mood swings

• Fatigue and bloating associated with high estrogen

This balanced combination helps maintain a healthy testosterone-to-estrogen ratio, which is crucial for optimal physical, sexual, and emotional health.

Clinical Applications

This combination capsule is ideal for:

1. Men with Secondary Hypogonadism

Stimulates natural testosterone production while preventing estrogen-related side effects.

2. Post-Cycle Therapy (PCT)

Used after anabolic steroid or TRT cessation to reactivate the HPG axis and prevent estrogen rebound.

3. Fertility Preservation

Enables testosterone optimization without suppressing sperm production or testicular size.

4. Estrogen-Dominant Hormonal Profiles

Beneficial for men with high estradiol symptoms alongside low to mid-range testosterone.

Clinical Benefits

Patients on this combination therapy often report:

• Restoration of normal or optimal testosterone levels

• Improved libido, energy, mood, and mental clarity

• Reduced risk of estrogen-related side effects

• Preserved fertility and testicular volume

• Increased sperm count (in fertility-focused treatment plans)

• Balanced hormonal homeostasis with minimal suppression

Dosing Guidelines

• Typical Enclomiphene dose: 12.5–25 mg per day

• Typical Anastrozole dose: 0.125–0.5 mg, taken 2–3 times per week or as per physician guidance

• Doses are customized depending on lab values and patient response

• Oral capsules are taken with or without food

• Regular hormonal monitoring is essential

Monitoring Parameters

Baseline and ongoing lab evaluations should include:

• Total and Free Testosterone

• Estradiol (E2)

• LH and FSH

• Semen analysis, if fertility is a goal

• Liver function, lipid panel, and hematocrit, as needed

Adjustments to anastrozole dosing may be made depending on estradiol trends.

Side Effects

Most patients tolerate this combination well. Potential side effects may include:

• Mild GI discomfort or headache

• Temporary mood fluctuations

• Low estrogen symptoms if over-suppressed (e.g., joint pain, dry skin, fatigue)

Side effects are typically dose-related and can be managed with adjustment.

Contraindications

• Active liver disease

• Hormone-sensitive cancers (e.g., prostate or breast)

• Allergy to either compound

• Not for use in women or pediatric patients

• Men with primary hypogonadism (testicular failure)

Storage & Handling

• Store in a cool, dry place (15–25°C / 59–77°F)

• Keep away from direct light and moisture

• Keep out of reach of children

• For use only under licensed medical supervision

Ideal Candidates

This formulation is best suited for:

• Men with secondary hypogonadism

• Patients recovering from androgenic steroid use

• Men with elevated estradiol symptoms

• Individuals seeking TRT alternatives with fertility retention

• Clinics offering personalized hormone protocols

Enclomiphene/Anastrozole Capsules deliver a smart, dual-acting solution for hormonal restoration—promoting natural testosterone synthesis while preventing estrogen-related disruptions. Designed for safety, performance, and fertility support, this therapy is a cornerstone of modern men’s health optimization.